Archives of internal medicine . <©) 0 ?53 ^^^-^•?y •^A < OD Fig. 1.—Effects of cowpox vaccination in man watched from day to day:A, first vaccination with cowpox. B, revaccination after short interval; earlyreaction. C, revaccination after long interval. D, traumatism alone. 410 THE ARCHIVES OF INTERNAL MEDICINE This is the immediate reaction designated early reaction in vaccinia(Fig. 1, second row, B). If a number of years have elapsed between thefirst vaccination and the second, the antibodies are no longer piesent butthe organism has retained the property to form them more quickly tha
Archives of internal medicine . <©) 0 ?53 ^^^-^•?y •^A < OD Fig. 1.—Effects of cowpox vaccination in man watched from day to day:A, first vaccination with cowpox. B, revaccination after short interval; earlyreaction. C, revaccination after long interval. D, traumatism alone. 410 THE ARCHIVES OF INTERNAL MEDICINE This is the immediate reaction designated early reaction in vaccinia(Fig. 1, second row, B). If a number of years have elapsed between thefirst vaccination and the second, the antibodies are no longer piesent butthe organism has retained the property to form them more quickly thanon the first occasion. Here we see that during the first days the organ-isms multiply (Fig. 1, third row, C) as in a first vaccination, the anti-bodies are produced more quickly and attack the micro-organisms afteronly four or five days. Since the micro-organisms have not had time tomultiply in sufiicient numbers, the amount of digestion products is rela- Days. 1 2 34 8. 15. ^ ^^^^f Anti^ en (horse- serum). (preoipit Fig. 2.—Formation of precipitin in rabbits after injection of horse-serum. Days ,1 18 . ,\El . . \?? |27. ? ? ? mjectioo Second injection
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