SPANISH FLU INFECTION
Virus H1N1, responsible for the deadly pandemy of Spanish flu in 1918 (colorized TEM). In 2005, Dr Terrence Tumpey (national Center for Infectious Diseases, CDC) succeded in rebuilding this virus from an avian influenza transmissible between human beings. His study will permit to understand better the modes of transmission of the virus H5N1 of the current avian influenza virus. Spanish flu virus, as all Influenza A virus, is a pleomorphic virus, which means that it can adopt different shapes according to the conditions. H1N1 virus can adopt a spherical or filamentous aspect. Spanish flu virus (H1N1) > Influenzavirus A > Influenzavirus > Orthomyxoviridae > RNA virus > Virus. This transmission electron micrograph (TEM) of an ultra-thin specimen revealed some of the ultrastructural morphologic features seen in 1918 influenza virus virions. The prominent surface projections on the virions are composed of either the hemagglutinin, or neuraminidase type of glycoproteins. Composed of what looked like dots or tubules, was a dense envelope known as a \capsid\, which surrounded each virions nucleic acid constituents.
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Photo credit: © CDC/TUMPEY/GOLDSMITH / BSIP / Alamy / Afripics
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