Materia medica and therapeutics : for physicians and students . tember. The rhizome and root-lets are the parts used. The rhizome is found in the shops inwrinkled, jointed, cylindrical pieces, about two lines in diameter,of a brown color externally, and yellowish within, having a tuftof about ten nearly simple fragile rootlets on its under powder is yellowish-gray, and has a sweetish smell; itstaste is at first sweetish, afterward bitter, acrid and alcohol is the best solvent of podophyllum, which hasbeen found to contain two resinous cathartic principles; one * A
Materia medica and therapeutics : for physicians and students . tember. The rhizome and root-lets are the parts used. The rhizome is found in the shops inwrinkled, jointed, cylindrical pieces, about two lines in diameter,of a brown color externally, and yellowish within, having a tuftof about ten nearly simple fragile rootlets on its under powder is yellowish-gray, and has a sweetish smell; itstaste is at first sweetish, afterward bitter, acrid and alcohol is the best solvent of podophyllum, which hasbeen found to contain two resinous cathartic principles; one * A Treatise on Poisons, 4th edition, p. 594. 34^ MATERIA MEDICA ECCRITICS. neutral, the other acid in reaction {^podophyllinic acid). Accord-ing to V. Podwissotzki, of Dorpat, podophyllum and podophyllinboth contain a resinous, bitter, amorphous substance, which isvery active and which he calls podopliyllotoxin. This consists oftwo principles, picropodophyllin (crystalline, bitter) and podo-phyllinic acid (inert). Power * has shown that the rhizome con- FlG. PODOPHYLLUM PELTATUM. tains no berberine nor any other alkaloid, and his investigationshave been confirmed by Maisch. Effects and Uses.—Podopliyllum is therefore an active liydra-gogue cathartic, with an especial determination to the upper Proceedings Am. Pharm. Assoc, 1877, p. 420. On the Resin of PodophyllumPeltatum. CATHARTICS CHELIDONIUM. 347 portion of the aliiiiottary canal, and a pretty decided cholagogueaction which, according to Rutherford, is due to stimulation ofthe hepatic secreting apparatus, and is greater when purgationis not profuse, and rvcr versa. He also concludes that purgationis due to intestinal irritation, which is essentially the conclusionreached by Anstie.* As a cholagogue and purgative, one of thefollowing pills may be given at bedtime : 3^ Resinae podophylli,gr. ij; extract! colocynthidis compositi, gr. xxiv; extract! bella-donnae, gr. iij. M. Ft. pil. xij. It is an ingredient in severalcatha
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