. A treatise on the nervous diseases of children, for physicians and students. oblongata, showing advancedchanges in ganglion cells. Hematoxylin-eosin stain. this change in the white fibres is the change in the gray matter not only ofthe cortex, but throughout the entire central nervous system. The changesare found to be the same in the cortex of the brain, in the cranial nerve nu-clei, and in the anterior and posterior gray matter from the cervical to thelumbar and sacral segments of the cord. Even the spinal ganglia showedsimilar changes. Our knowledge of the spinal changes we owe chiefly to
. A treatise on the nervous diseases of children, for physicians and students. oblongata, showing advancedchanges in ganglion cells. Hematoxylin-eosin stain. this change in the white fibres is the change in the gray matter not only ofthe cortex, but throughout the entire central nervous system. The changesare found to be the same in the cortex of the brain, in the cranial nerve nu-clei, and in the anterior and posterior gray matter from the cervical to thelumbar and sacral segments of the cord. Even the spinal ganglia showedsimilar changes. Our knowledge of the spinal changes we owe chiefly toDr. Hirsch, whose findings I have been able to corroborate in a case exam-ined by me only a few years ago. There can no longer be any doubt thatthe disease is due to a degeneration of the ganglion cells throughout the en-tire central nervous system. In the cortex, as well as in the gray matter of AMAUROTIC FAMILY IDIOCY. 467 the cord, there is scarcely a normal ganglion cell to be seen. As will benoted from the illustrations herewith presented (see Figs. 117-119), the >w. Fig. 118.—Section through cervical enlargement, showing cell changes in anteriorgray matter. (Van Gieson stain.) cell-body is completely altered; the entire cell protoplasm has become disin-tegrated, leaving a more or less homogeneous mass; the nucleus has been
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Keywords: ., bookcentury1900, bookdecade1900, booksubject, booksubjectchildren
