. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. 88 L. F. GAINEY ET AL Table 3 .•\iitiixniii.\t.\ thai Inn/ an we/»/H<mr effect upon the action of 5HT and DA Antagonist T\ PL' Agonistt Mean contraction ratio ± SD l/i)i PI Ergonovine DA/5HT 5HT ± .38 (4) NAN- 190 5HT1A 5HT ± .52 (6) Ketan serin 5HT, 5HT ± .15 (6) Ritanserin 5HT2 5HT ± .67 (7) MDL 72222 5HT, 5HT ± .73 (6) Tropisetron 5HT3 5HT ± (6) Bulhucapnine DA DA ± (6) Butaclamol DA DA ± (17) Ergonovine DA/5HT DA ± (4
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. 88 L. F. GAINEY ET AL Table 3 .•\iitiixniii.\t.\ thai Inn/ an we/»/H<mr effect upon the action of 5HT and DA Antagonist T\ PL' Agonistt Mean contraction ratio ± SD l/i)i PI Ergonovine DA/5HT 5HT ± .38 (4) NAN- 190 5HT1A 5HT ± .52 (6) Ketan serin 5HT, 5HT ± .15 (6) Ritanserin 5HT2 5HT ± .67 (7) MDL 72222 5HT, 5HT ± .73 (6) Tropisetron 5HT3 5HT ± (6) Bulhucapnine DA DA ± (6) Butaclamol DA DA ± (17) Ergonovine DA/5HT DA ± (4) Apomorphtne DA2 DA ± (7) Chlorpromazine DA, DA ± (5) Fluphenazine DA, DA ± (6) Pimozide DA, DA ± (6) Spiperone DA; DA ± (16) Sulphide DA,,, DA ± (8) * The primary type of mammalian receptor blocked by the antagonist. t Agonist concentrations: 5HT = 2x 10~5 M; DA = 5X 10~5 M. Antagonist concentrations were 10 4 M. t Contraction ratio: height of contraction after exposure to the antagonist/height ot contraction before exposure to the antagonist. §P values are one-tailed probabilities. ANOVA was performed, none of the contraction ratios were significantly different from each other [F(2. 132) = ; P = ]. These control responses rendered the usual analytical techniques inapplicable, so the effects of antagonists were examined with the statistical tests described in the Methods section. • 5HT. The effects of 5HT were inhibited by the 5HT2 antagonists cyproheptadine and mianserin. The 1C,,, for cyproheptadine was X 10 7 M. while that for mianserin was X 1()~? M. These antagonists also blocked the effects of DA and, unexpectedly, caused ACh to relax the gill muscles (Table 2). The following 5HT antagonists were ineffective at 10 4 M: ergono- vine, NAN-190, ketanserin. ritanserin, MDL 72222. and tropisetron (Table 3). • DA. SKF-83566. a DA, antagonist
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