Sajous's analytical cyclopædia of practical medicine . ast, very impressive. Hyperactivity of the anterior lobeof the pituitary coming on before thecompletion of epiphyseal ossification,results in giantism, that is to say, theindividual is overgrown but wellproportioned. After epiphyseal ossi-fication is complete, however, hyper-activity of the hypophysis results in Symmers (Interstate Med. Jour.,Nov., 1917). COURSE AND DURATION.— Established acromegaly is generallyobserved in adults, male or initial dystrophic phenomena ap-pear at the age of 18 to 25 years, the period in wh
Sajous's analytical cyclopædia of practical medicine . ast, very impressive. Hyperactivity of the anterior lobeof the pituitary coming on before thecompletion of epiphyseal ossification,results in giantism, that is to say, theindividual is overgrown but wellproportioned. After epiphyseal ossi-fication is complete, however, hyper-activity of the hypophysis results in Symmers (Interstate Med. Jour.,Nov., 1917). COURSE AND DURATION.— Established acromegaly is generallyobserved in adults, male or initial dystrophic phenomena ap-pear at the age of 18 to 25 years, the period in which, under normalconditions, growth is continued and ACROMEGALY (LAUNOIS AND CESBRON). 293 completed. Sometimes it is headache isted, and under these conditions the which leads the std:)ject to consult a question arises in our minds whether physician. Other victims, frightened they could not have created a disturb- at seeing their hands and feet grow ance in the hypophysis, as well as in the larger, come to hnd out the reason other ductless Base of cranium of the griant Constantin. showinsr marked enlargement ot sellatuicica. {Dufrane and F. E Launois.) for these changes. In women theoutset of the disease may be tracedwith some degree of probability to aperiod at which menstruation becameirregular or ceased. We must recognizethat such indications are rather vague,as is also the information obtained fromthe past morbid history. Sometimes in-fectious diseases are found to have ex- The dystrophy seems to occur withgreater frequency in women than inmen. Taking the combined statistics ofSouza-Leite and of Duchesneau,we find22 men were affected as against 31women. While the onset of the disease issometimes delayed (forty-nine years ina case of Schwartz), it can also be pre- 294 ACROMEGALY (LAUNOIS AXD CESBRON). cocious, and the few cases of this kindrecorded have made it possible to de-scribe the acromegaly of children orof adolescents. Race is without influence in the et
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