. The endocrine organs; an introduction to the study of internal secretion . lls,so that a part if not the whole ofthe corpus luteum is formed fromthe epithelium which originally linedthe Graafian follicle. In the human subject,-as inthe lower mammals, the lutealcells at first form a layer liningthe wall of the follicle. Pre-sently this layer becomes plaitedinto thick folds tending to con-verge towards the cicatrix ofthe follicle. After a time thecells forming the folds undergoa peculiar change; they losetheir distinct outlines, becomestained with great difficulty, andare closely clumped toget
. The endocrine organs; an introduction to the study of internal secretion . lls,so that a part if not the whole ofthe corpus luteum is formed fromthe epithelium which originally linedthe Graafian follicle. In the human subject,-as inthe lower mammals, the lutealcells at first form a layer liningthe wall of the follicle. Pre-sently this layer becomes plaitedinto thick folds tending to con-verge towards the cicatrix ofthe follicle. After a time thecells forming the folds undergoa peculiar change; they losetheir distinct outlines, becomestained with great difficulty, andare closely clumped together inthick trabecula3, the whole hav-ing a characteristic appearanceand distinct yellow colour. The corpus luteum is wellmarked throughout pregnancy,although towards the end it be-comes less sharply defined fromthe ovarian stroma. Similarchanges occur—but with far less increase in size—in burst follicles where pregnancy has not corpora lutea thus produced have been termed corpora lutea spuriato distinguish them from the corpora lutea vera of k FIG. 95.—Part of the section shown in fig. 200 diameters. EFFECTS OF REMOVING AND REIMPLANTING OVARIES The effects resulting from removal of both ovaries (oophorectomy; spay-ing) are externally not so striking as with the similar operation in themale sex. If the operation is performed in young animals, or if the ovariesare congenitally atrophic, it is not infrequently found that charactersdistinctive to the male are to some extent assumed. In the human subject,as well as in animals, a constant result is that the uterus remains small: 140 The Endocrine Organs the external changes characteristic of puberty either do not occur or aregreatly modified : there is absence of menstruation. A tendency to the maletype of trichosis is often also exhibited. When the operation is performedsubsequently to puberty the results are less marked—but menstruationceases, and there is sometimes atrophy of the ma
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