. The thyroid gland in health and disease. ffecal material fromgoitrous persons, pointing to the specific nature of the toxic excitant(figs. 25, 34). (2) Approximately 63 per cent, were born with congenitalgoitre. This result was observed amongst the offspring of goitrousrats receiving aerobic or anaerobic cultures from the faeces ofgoitrous persons : the latter being the more potent to cause thecondition. (3) Approximately 32 per cent, were born with congenitaldisease of the parathyroid glands. This result was observed onlyamongst the offspring of goitrous rats fed during pregnancy onanaerobi
. The thyroid gland in health and disease. ffecal material fromgoitrous persons, pointing to the specific nature of the toxic excitant(figs. 25, 34). (2) Approximately 63 per cent, were born with congenitalgoitre. This result was observed amongst the offspring of goitrousrats receiving aerobic or anaerobic cultures from the faeces ofgoitrous persons : the latter being the more potent to cause thecondition. (3) Approximately 32 per cent, were born with congenitaldisease of the parathyroid glands. This result was observed onlyamongst the offspring of goitrous rats fed during pregnancy onanaerobic cultures from the faeces of goitrous persons, or on the 115 116 EXPERIMENTAL CONSIDERATIONS faecal filtrate from such persons, a finding which points to thespecific action of the products of these micro-organisms. (4) Approximately 33 per cent, were born with normal, orrelatively normal, thyroid and parathyroid glands. (5) Where there was congenital disease of the parathyroidglands there was also congenital disease of the thyroid Fig. 49.—Section of normal thyioids isthmus from a 4-day-old rat. X case as Fig. 66. In rare cases, however, the thyroid was less severely affected than the parathyroid. In no case did any of the numerous offspring of the control animals exhibit thyroid fibrosis or parathyroid findings admit of the following conclusions :—-(a) As congenital parathyroid disease is comparatively common amongst the offspring of goitrous rats, it is presumable that it is also comparatively common amongst the offspring of goitrous human beings. EXPERIMENTAL CONSIDERATIONS 117 (/;) Congenital parathyroid disease is due to the action on thefoetal parathyroid glands of the toxic products of anaerobicorganisms absorbed from the maternal intestine. (c) Congenital goitre is due to a like cause, but the thyroidswelling may be induced by organisms capable of growth underaerobic or anaerobic conditions—the latter being the more potent.
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