Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . ons of diphtheria are probably dueto an intracellular toxin (endotoxin). Schwoner has demonstratedthat the diphtheria bacillus produces a hernolytic toxin (diphtherioly-sin) which acts principally on the red blood-cells. Babonneux, inanimals, has succeeded in producing a localized paralysis restrictedto the region of the inoculation, not generalizing, often ending inrecovery, and in other ways resembling the diphtheritic paralysisoccurring late in, or coming on after, diphtheria of ma
Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . ons of diphtheria are probably dueto an intracellular toxin (endotoxin). Schwoner has demonstratedthat the diphtheria bacillus produces a hernolytic toxin (diphtherioly-sin) which acts principally on the red blood-cells. Babonneux, inanimals, has succeeded in producing a localized paralysis restrictedto the region of the inoculation, not generalizing, often ending inrecovery, and in other ways resembling the diphtheritic paralysisoccurring late in, or coming on after, diphtheria of man. Rolleston,Bolton, and others are of the opinion that the diphtheritic paralysisin man is due to some endotoxin. The fact that the antitoxin treat-ment of diphtheria has greatly reduced the mortality, but not materiallyinfluenced the occurrence of paralysis, speaks in favor of this is argued that the prevailing method of inducing immunity in horses,by the use of filtered cultures, affords an antitoxin for the extracellularpoisons but offers no protection from the intracellular toxin (endotoxin).. Fig. 66.—Margin of Membrank from Tonsil, Case , A. Diphtheria bacilli; the pointer from the lower .-I endsin an area of granular material. B Cocci. C, Strands offibrin. The cellular elements present are squamous epithelium,and polymorphonuclear and hyaline leukocytes. HAITKRIA AS CAUSKS ()K DISK ASK. I 21 It is also possible that the diphtheritic j)aralysis may he <luc to somepoison resemblinj^ or related to the toxone described by Khrlich. Boltonpartioularlv adheres to the belief that affections of the peripheral nervesare due to the action of a toxone. Diphtheria Antitoxin.—The antitoxic treatment ol dij)hthena isone of the most brilliant achievements that has followed the laboratorystudy of disease. Repeated administration of diphtheria toxin givesrise to powerful antitoxic bodies which are contained in the circulatingblood of the animal treated and ma
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