The Pharmacology of Pyraconitine and Methylbenzaconine Considered in Relation to Their Chemical Constitution . Methylbenzaconine on Mammalian Heart Methylbenzaconine on Mammalian Heart and Pulse. and Pulse. (The levers write upwards in systole.) ?^/V-/\--v-^ ; \ ; LVwt. I, Van —Pulse —Pulse dl, 120 mins. after methylbenzacon., 0125 gramme auric, to three ventcl. contractions. el, three auric, to one effective P 2 108 PEOFESSOES J. T. CASH AND W. B. DUNSTAN ON THE The vaso-eonstrictor centre is early depressed by methylbenzaconine, its responseto sensory stimulation
The Pharmacology of Pyraconitine and Methylbenzaconine Considered in Relation to Their Chemical Constitution . Methylbenzaconine on Mammalian Heart Methylbenzaconine on Mammalian Heart and Pulse. and Pulse. (The levers write upwards in systole.) ?^/V-/\--v-^ ; \ ; LVwt. I, Van —Pulse —Pulse dl, 120 mins. after methylbenzacon., 0125 gramme auric, to three ventcl. contractions. el, three auric, to one effective P 2 108 PEOFESSOES J. T. CASH AND W. B. DUNSTAN ON THE The vaso-eonstrictor centre is early depressed by methylbenzaconine, its responseto sensory stimulation becoming feeble as poisoning proceeds, and to this as well as tothe slowed pulse the steady and extensive fall of pressure is due. The innervation ofthe vessels is slightly interfered with, as splanchnic (peripheral) stimulation is reducedin effect, though operative in degree, throughout. The respiratory centres are early and progressively reduced in activity. Whilstintramuscular motor nerves are depressed in function, in no instance has the reactionof the sciatic been suspended even by lethal doses of methylbenzaconine. —G&k of 3020 grammes, etherised, placed in warm box, cannulas intrachea and right carotid artery. Left splanchnic, left vagus, and left sciaticdivided, on electrodes. Pericardium opened. Left auricle and left ventricle attachedto recipient tambours in pneumatic connection with recording tambour
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