. Bulletin of the Department of Agriculture. Agriculture; Agriculture. UNITED STATES DEPARTMENT OF AGRICULTURE. Jfc BULLETIN No. 340 55klkS>/4l^» Contribution from the Bureau of Animal Industry A. D. MELVIN, Chief jplW^Ltu Washington, D. C. PROFESSIONAL PAPER December 27, 1915 EXPERIMENTS IN VACCINATION AGAINST By Adolph Eichhorn, Chief of the Pathological Division. CONTENTS. Page. Prevalence of anthrax and methods of con- trol 1 Protective vaccination 2 Production of serum 4 Standardization of the serum 7 Experimental data 8 Hyperimmunization of horses 8 Serum tests 9 Page.
. Bulletin of the Department of Agriculture. Agriculture; Agriculture. UNITED STATES DEPARTMENT OF AGRICULTURE. Jfc BULLETIN No. 340 55klkS>/4l^» Contribution from the Bureau of Animal Industry A. D. MELVIN, Chief jplW^Ltu Washington, D. C. PROFESSIONAL PAPER December 27, 1915 EXPERIMENTS IN VACCINATION AGAINST By Adolph Eichhorn, Chief of the Pathological Division. CONTENTS. Page. Prevalence of anthrax and methods of con- trol 1 Protective vaccination 2 Production of serum 4 Standardization of the serum 7 Experimental data 8 Hyperimmunization of horses 8 Serum tests 9 Page. Preparation of spore vaccine 10 Technic of administration 11 Test of the simultaneous method on cattle and sheep 13 Fisld tests 13 Treatment of anthrax in man 15 Concentration of serum 15 Conclusions 16 PREVALENCE OF ANTHRAX AND METHODS OF CONTROL. Anthrax is a disease that is widely spread throughout the world, and in the United States it is being recognized as one of the most destructive scourges of live stock. In certain sections it is more prevalent than in others, particularly in the Southern States, and since no determined effort has been made toward its suppression it appears to be on the increase, its presence now being recorded in localities where it has never before been recognized. As the spores of the causative agent of anthrax retain their virulence and remain lodged in the soil in an active state for many years in the infected localities, it is very difficult to prevent the spread of the infection, and the eradication of the disease is thereby rendered a most serious problem. Various factors have to be considered in the prophylactic control of anthrax, such as the prevention of the continued impregnation of 1 The author was ably assisted in the technical part of this work by Dr. Raymond A. Kelser, assistant in pathology and bacteriology, to whom credit is due for the painstaking and careful execution of the details of the experiments. Note.—This bulletin is of
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