Diseases of the nervous system : a text-book of neurology and psychiatry . e of action of the internal secretions on thegrowth of muscle and of bone and other connective tissues. The possibility of this beinga vasomotor reflex mechanism is indicated by lines marked? (Paton.) chemical regulators may be effective-—thus one must explain the posi-tive and negative tropisms within the cells of an organ in its initialresponse to a disturbance of cellular adjustment—yet the chief activ-ities of the internal secretions are brought about by neurochemicalregulators, as Paton terms them. 172 THE ENDOCRIN
Diseases of the nervous system : a text-book of neurology and psychiatry . e of action of the internal secretions on thegrowth of muscle and of bone and other connective tissues. The possibility of this beinga vasomotor reflex mechanism is indicated by lines marked? (Paton.) chemical regulators may be effective-—thus one must explain the posi-tive and negative tropisms within the cells of an organ in its initialresponse to a disturbance of cellular adjustment—yet the chief activ-ities of the internal secretions are brought about by neurochemicalregulators, as Paton terms them. 172 THE ENDOCRINOPATHIES Just as the complicated sensori-motor integrations are effectivein governing the muscular activities of the. human body, so theintegration of neurochemical regulators, taking place at the physico-chemical level, is effective in adjusting the metabolism of the bodycells. Hormones are not the activators primarily; they are the ser-vants of the vegetative nervous system. All of the endocrinopathiesare really polyglandular syndromes and under psychical Fig. 64.—Scheme of innervation of the liver, spleen, and kidney. nX, nucleus of thevagus; -X, vagus; nv, vasomotor nucleus in medulla; s, sympathetic; re, rami commu-nicans; spl, splanchnic nerve; ps, solar plexus; gs, semilunar ganglion; spl, spleen.(Bechterew.) Pancreatic Syndromes.—Falta holds that the chief activity of thepancreas is subserved through an assimilatory hormone, which controlsthe glycogenesis of the liver and muscles. In mild grades of pancreaticinsufHciency disturbances of carbohydrate metabolism appear onlywhen great demands are made upon the glycogenic function of theliver through excessive alimentary carbohydrate intake. In graverdisturbances in addition to the modification of anabolism a high POLYGLANDULAR SYNDROMES 173 grade of catabolic destruction takes place with a failure to formhigher and lower fatty acids (ketonuria). Pancreatic syndromes occur as a result of gross anatomical d
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