Transactions of the Royal Society of Edinburgh . one result, viz., a diminution in the amount ofbile and bile-solids secreted after the administration of these doses. Scottsexperiment appears to have been very carefully conducted. Its result wasso much at variance with the prevalent opinion regarding the action of calomelin man, that some authorities alleged that there must be some differencebetween the action of mercurials on man and on the dog. Impressed withthe necessity for obtaining precise information with regard to this point andothers, Hughes Bennett organised the committee to which re
Transactions of the Royal Society of Edinburgh . one result, viz., a diminution in the amount ofbile and bile-solids secreted after the administration of these doses. Scottsexperiment appears to have been very carefully conducted. Its result wasso much at variance with the prevalent opinion regarding the action of calomelin man, that some authorities alleged that there must be some differencebetween the action of mercurials on man and on the dog. Impressed withthe necessity for obtaining precise information with regard to this point andothers, Hughes Bennett organised the committee to which reference hasalready been made. The committee settled beyond all possibility of doubt thatmercury produces in the dog the same general effects as in man (Op. v. p. 201).When small but increasing doses of corrosive sublimate were injected underthe skin for several days in succession, salivation occurred, the breath becamefoetid, the gums ulcerated, emaciation ensued, and in dogs without biliaryvol. xxix. part i. 3 P 238 PROFESSOR RUTHERFORD ON THE. Fig. 75.—Secretion of bile before and after calomel given without bile. 10grains calomel in 7 cc. water injected into duodenum at c, and againat c. Experiment 75. fistulas (when therefore the bile was discharged into the intestine), the drug setup profuse diarrhoea, while in dogs with biliary fistulas there was no significance of this fact struck no one at the time, but the experimentshereafter to be detailed furnish what is probably the true explanation (see ). The committee further found (Op. cit. p. 214) that when calomel wasadministered to dogs with permanent biliary fistulas in doses of one-twelfthof a grain given from six to fourteen times daily, and in doses of 2 grains fromtwo to six times daily, it did not increase the biliary secretion, nor did it pro-duce purgation; but whengiven in doses of 10 grainsonce a day, it produced pur-gation and diminished thebiliary secretion. Morerecently experiments wereperfo
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