. The Biochemistry of B vitamins. Vitamins; Vitamin B complex. RIBOFLAVIN 677 week. L-Araboflavin (200 y per day), which possesses some growth- promoting properties itself, appears to reduce very slightly the growth of rats receiving low amounts of riboflavin (10 y per day).22 D-Arabo- flavin, at a concentration of 25 y per cc, also inhibits the growth of an unidentified strain of lactic acid bacteria. Galactoflavin [6,7-Dimethyl-9-(D,l'-dulcityl)isoalloxazine]. The admin- istration of galactoflavin ( to mg) daily by stomach tube increases the mortality rate and decreases the rate of g
. The Biochemistry of B vitamins. Vitamins; Vitamin B complex. RIBOFLAVIN 677 week. L-Araboflavin (200 y per day), which possesses some growth- promoting properties itself, appears to reduce very slightly the growth of rats receiving low amounts of riboflavin (10 y per day).22 D-Arabo- flavin, at a concentration of 25 y per cc, also inhibits the growth of an unidentified strain of lactic acid bacteria. Galactoflavin [6,7-Dimethyl-9-(D,l'-dulcityl)isoalloxazine]. The admin- istration of galactoflavin ( to mg) daily by stomach tube increases the mortality rate and decreases the rate of growth of rats on a ribo- flavin-free diet. The analogue ( mg per day) completely inhibits the -CH2OH. O galactoflavin [6,7-dimethyl-9-{D ,1' -dulcityl)isoalloxazine\ response of the animals to 10 y daily of riboflavin and markedly inhibits the response to 40 y daily of the vitamin. The inhibitory effect of mg of the analogue is almost, but not completely, prevented by 200 y per day of riboflavin. The index at which growth inhibition is noted is approxi- mately 10. Lumichrome and Lumiflavin. The growth of a mutant strain (51602) of Neurospora which requires riboflavin when incubated at 31-34° C, but not when incubated at 25° C, is inhibited by both lumichrome and lumi- The inhibition resulting from either compound is competitively prevented by riboflavin. In tests incubated for 84 hours at 31° C, the inhibition index for lumichrome was for half-maximum and 6-8 for complete inhibition of growth. Lumiflavin was only about one- twentieth as effective as CH3 N NH N N CH3-L^>X ^Cx Jm CH3-l^Jx A .NH N C N C H o lumichrome lumiflavin (6,7-dimethylalloxazine) (6,7,9-trimethylisoalloxaziiie). Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Williams, Roger John, 1893-. New
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