. Ciba Foundation symposium on drug resistance in micro-organisms: mechanisms of development. Drug resistance in microorganisms. INHERITANCE IN SINGLE BACTERIAL CELLS W. Howard Hughes Wright-Fleming Institute of Microbiology, St. Mary's Hospital, London When Demerec (1948) presented his views on stepwise mutations he stimulated a number of independent workers to challenge them (Hughes, 1952: Eagle, Fleischman and Levy, 1952; Mayr-Harting, 1955). While agreeing with the general. 005 0-01 0-02 0-03 004 Penicillin concentration () Fig. 1. Titration of sensitivity of single-cell strains of s
. Ciba Foundation symposium on drug resistance in micro-organisms: mechanisms of development. Drug resistance in microorganisms. INHERITANCE IN SINGLE BACTERIAL CELLS W. Howard Hughes Wright-Fleming Institute of Microbiology, St. Mary's Hospital, London When Demerec (1948) presented his views on stepwise mutations he stimulated a number of independent workers to challenge them (Hughes, 1952: Eagle, Fleischman and Levy, 1952; Mayr-Harting, 1955). While agreeing with the general. 005 0-01 0-02 0-03 004 Penicillin concentration () Fig. 1. Titration of sensitivity of single-cell strains of staphylococci using small implants. Key to curves: , parent strain; , single-cell strain I; •-•-•, single-cell strain II. Parent strain and strain I give a value of 0-0325 for 0% survivors. Strain II gives a value of 0-035 under identical conditions. (Hughes, W. H. (1952), J. gen. Microbiol, 6, 175.) picture of the emergence of resistance as he painted it, the present author objected to his conclusions that there were clearcut steps in the process, believing the steps might be artifacts imposed by the limitations of titration methods generally. It seemed that only by working throughout with single cell isolates or by maintaining a continuous photo- graphic observation would it be possible to settle this question. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation; Wolstenholme, G. E. W. (Gordon Ethelbert Ward); O'Connor, Cecilia M. (Cecilia Mary), 1927-. Boston, Little, Brown
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