Sex reversal in mice: a chromosomally-female (XX) mouse carrying the Sry-gene (sex-determining region Y gene) that has caused it to grow as a male wit

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Sex reversal in mice: a chromosomally-female (XX) mouse carrying the Sry-gene (sex-determining region Y gene) that has caused it to grow as a male with testes. This mouse is a product of research led jointly by Robin Lovell-Badge of the Medical Research Council & Peter Goodfellow of the Imperial Cancer Research Fund. A number of embryos were injected with a small fragment of Y chromosome DNA containing the Sry-gene; sex reversal occurred in some of the females. Sry is believed to act as a switch in the complex gene mechanism that diverts mammalian development from its usual course - the female - to the male.

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Photo credit: © MEDICAL RESEARCH COUNCIL/SCIENCE PHOTO LIBRARY / Alamy / Afripics
License: Licensed
Model Released: No

Keywords: animal, biological, biology, experiment, experimentation, gene, genetics, maleness, mice, mouse, research, science, scientific, sex, sex-determining, sry, testis-determining, transgenic