Archives of internal medicine . quently they are exhausted more and more until C. E. VON PIRQVET 421 after the injection /, the zero point is approached. As the tuberculininjections can only elicit a general reaction if the tuberculin meets withthe antibody, the general reactions are lessened every time, and at point gno reaction at all occurs. After the last injection the antibodies haveagain time to enter the circulation. This is clearly shown in the effectof the cutaneous tests. The cutaneous reactions before a are equal; afterb, however, the test is made at a time when the antibody is pres
Archives of internal medicine . quently they are exhausted more and more until C. E. VON PIRQVET 421 after the injection /, the zero point is approached. As the tuberculininjections can only elicit a general reaction if the tuberculin meets withthe antibody, the general reactions are lessened every time, and at point gno reaction at all occurs. After the last injection the antibodies haveagain time to enter the circulation. This is clearly shown in the effectof the cutaneous tests. The cutaneous reactions before a are equal; afterb, however, the test is made at a time when the antibody is present onlyin amounts a little over the threshold of cutaneous reactivity, thereforethe reaction is small. The next time the reactions are completely nega-tive, and only several days after the last injection of tuberculin thereaction reappears with the rising of the antibody content over thethreshold of cutaneous reactivity. In the special section on tuberculosis Days. _lS. J^^ 1^2. ^4; Dea\b limit Supposed ^rouath of tuberculosis. Fig. 15.—Influence of measles on tuberculosis. we became acquainted with two other reasons for a lessened reactivity totuberculin. These are the conditions existing in measles and miliarytuberculosis. Figure 15 gives a scheme illustrative of both of theseprocesses. It is constructed on the basis of a case observed by antibody is measured with daily cutaneous tuberculin tests; thefever curve, indicating the amount of the secondary toxic body, is copiedfrom the chart. The growing of the tubercle bacilli is hypothetical butconfirmed at the end by the post-mortem examination. The amount oftuberculin antibody remains unchanged for the first days of the feverof measles; it begins to decrease rapidly with the appearance of theexanthem. My hypothesis is that the tubercle germs, kept in check until 422 TEE ARCHIVES OF INTERNAL MEDICINE now by the antibodies, grow unobstruetedly and spread during thatperiod of anergy. After that period, owing to meas
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