. The endocrine organs; an introduction to the study of internal secretion . effect; whereas its action duringparturition is well established. Engeland and Kutscher claim to have isolated an autacoidwhich affects the uterus only. 88 The Endocrine Organs of the excised eye of the frog (W. Cramer). In some of these actions it re-sembles adrenalin, but the stimulating autacoid of the pituitary is certainlydifferent both chemically and in its physiological reactions from that ofthe suprarenal. For it does not specifically stimulate structures innervatedby the sympathetic as does adrenalin ; moreov
. The endocrine organs; an introduction to the study of internal secretion . effect; whereas its action duringparturition is well established. Engeland and Kutscher claim to have isolated an autacoidwhich affects the uterus only. 88 The Endocrine Organs of the excised eye of the frog (W. Cramer). In some of these actions it re-sembles adrenalin, but the stimulating autacoid of the pituitary is certainlydifferent both chemically and in its physiological reactions from that ofthe suprarenal. For it does not specifically stimulate structures innervatedby the sympathetic as does adrenalin ; moreover, neither apocodeine norergotoxine affect the results obtained with it. Probably it acts as a directstimulus upon the contractile substance of the cells which it influences. Effects on Kidney. — The renal arteries form an exception to the con-strictor effect produced by pituitary extract, since they dilate as a con-sequence of the addition of the extract to the circulating blood (fig. 60) :the dilatation is correlated with an increase of secretion of urine (figs. 60,. FIG. 59.—Tracing showing the action on an isolated cornu of rats uterus suspended in Lockessolution, of the addition of extract of posterior lobe of ox pituitary to the solution. (M. Itagaki.) 61, 62): it is often preceded by a slight contraction, and the increase ofurine by a temporary diminution. The increased secretion may be in partbrought about by the increased flow of blood through the kidney vessels,due to the circumstance that they undergo dilatation, while all the othersystemic arteries are contracting; but that it is to a certain extent causedby a specific effect of one of the pituitary autacoids is probable from thefact that it may occur in the absence of any obvious arterial change. Moreover, an increased rate of flow is maintained after the blood-pressurehas come back to the level at which it stood before the injection. And theeffect of a second and subsequent doses of the autacoid administered
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