Gynecology . ion of the ovaryrepresents a repeated ripening of the primordial follicles. They can be seenin lessening numbers up to the time when ovulation ceases at the menopause. (2) The Ripening Follicle.—When the follicle begins to ripen the surround-ing epithelial cells begin to multiply by mitosis and to heap up into several 34 GYNECOLOGY layers. The cells now assume a larger and more cuboidal form and lie closelyaround the egg. Soon in this mass of cells there appears a vacuolization, orclear space, which becomes filled with fluid, the so-called liquor folliculi. Theclear place containi
Gynecology . ion of the ovaryrepresents a repeated ripening of the primordial follicles. They can be seenin lessening numbers up to the time when ovulation ceases at the menopause. (2) The Ripening Follicle.—When the follicle begins to ripen the surround-ing epithelial cells begin to multiply by mitosis and to heap up into several 34 GYNECOLOGY layers. The cells now assume a larger and more cuboidal form and lie closelyaround the egg. Soon in this mass of cells there appears a vacuolization, orclear space, which becomes filled with fluid, the so-called liquor folliculi. Theclear place containing the liquid is crescentic in form, partly encompassing theegg. Several layers of epithelial cells continue to envelop the egg, and themass thus formed juts out into the liquor like a peninsula. The collection ofprotecting cells that surround the egg is called the discus proligerus (or cumulusoophorus), while the rest of the epithelium around the periphery of the follicleis called the membrane/, Fig. 10.—Graafian power. Three follicles are seen which are in the earliest stages. The center one hasbegun to show proliferation of the cells. These cells were originally derived from the germinal epi-thelium covering the ovary. No ova are seen. At the same time that these changes are going on inside the follicle, it isbeing surrounded on the outside by a concentric envelope of connective tissue,termed the theca folliculi. This envelope is plainly divided into two layers,that lying farthest away from the follicle being termed the tunica or theca ex-terna, and that lying next to the follicle being called the tunica or theca tunica externa is thick and dense and consists of circularly arrangedconnective-tissue fibers. It contains the blood- and lymph-vessels that supply PHYSIOLOGY OF THE UTERUS AND OVARIES 35 imh
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