. The American journal of roentgenology, radium therapy and nuclear medicine . astic osteoclasis rarely involves thebone in a uniform fashion. In the roent-genogram the diseased portions are fre-quently irregular in outline and have amoth-eaten appearance. Conspicuousshortening of bone occurs when thedestructive process is of sufficient the osteoplastic type of metastaticcarcinoma much osteoid or osseous forma- n The American Roentgen Ray Society, 1921. / 712 Two Cases of Localized Metastatic Carcinoma of Vertebrae tion occurs. The new bone formationprobably takes place through stimul
. The American journal of roentgenology, radium therapy and nuclear medicine . astic osteoclasis rarely involves thebone in a uniform fashion. In the roent-genogram the diseased portions are fre-quently irregular in outline and have amoth-eaten appearance. Conspicuousshortening of bone occurs when thedestructive process is of sufficient the osteoplastic type of metastaticcarcinoma much osteoid or osseous forma- n The American Roentgen Ray Society, 1921. / 712 Two Cases of Localized Metastatic Carcinoma of Vertebrae tion occurs. The new bone formationprobably takes place through stimulationor increased activity of preserved osteo-blasts, the tumor acting as the may also be that the irritation andconsequent osteoblastic stimulation dependupon occlusion by tumor cells of some ofthe vessels of the bone. Some of thenewly-formed osteoid tissue may alsoarise through metaplasia of the fibrousstroma of the tumor. In any case the new-tissue may remain osteoid for a long period,or it may gradually become very solid,compact and osseous. The osteoplastic. Fig. 4. (a) Anteroposterior view of lower thoracic verte-brae showing a metastatic carcinoma of the gth thoracicvertebra, (b) Lateral view of same lesion showing com-pression from carcinomatous bone destruction. ]Droperty of some tumors is so marked thatthey may transform some portions of theinvolved bone into an ivory-hard such cases a roentgen-ray diagnosis issometimes clifTicult, and the dense areasmay be mistaken tor non-neoplastic diseaseof the bones. In most cases, however, theirregular increase in densitv and the Basle. In 63 cases of carcinoma of themammary gland, bone metastasis occurred33 times, or in ^2 per cent; and in 24 casesof prostatic cancer, 16 times. But in 309cases of gastric carcinoma only percent showed bony metastasis; in 159 casesof uterine carcinoma, only 5 per cent; inloi cases of esophageal carcinoma, percent, and in 57 cases of carcinoma of therectum, per
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