Intravenous injection in wound shock : being the Oliver-Sharpey lectures delivered before the Royal College of Physicians of London in May 1918 . Fig. 17.—Hydrogen-ion Concentration for Frogs Heart. Perfusion fluid with hydrogen-ion concentration of lO-10* N. ii. Do. Do. do. 10-72 N. N> C02 added to make No. ii. (Mines, 1913, p. 20.) Fig. 16), and that Bedford (1917) has shown that inshock there is an increase in the adrenaline contentof the blood. The experiments of Mines (1913)show that a very faintly acid reaction is the optimalcondition for the heart (Fig. 17). Cl
Intravenous injection in wound shock : being the Oliver-Sharpey lectures delivered before the Royal College of Physicians of London in May 1918 . Fig. 17.—Hydrogen-ion Concentration for Frogs Heart. Perfusion fluid with hydrogen-ion concentration of lO-10* N. ii. Do. Do. do. 10-72 N. N> C02 added to make No. ii. (Mines, 1913, p. 20.) Fig. 16), and that Bedford (1917) has shown that inshock there is an increase in the adrenaline contentof the blood. The experiments of Mines (1913)show that a very faintly acid reaction is the optimalcondition for the heart (Fig. 17). Clark (1913) foundthat a change from a PH of 77 to one of 65 had notmuch effect on the frogs heart for the first twentyminutes, but decreased the beat in eighty minutes. IN WOUND SHOCK 5i The Arterioles.—Gaskell (1880) showed thatvery weak lactic acid dilated the arterioles. I con-firmed this (1901) and found that one part of lacticacid in 10,000 parts of Ringers solution had about. Fig. 18.—Effect of Carbon Dioxide on the BloodVessels of the Frog. Hind legs perfused with Ringers solution. Upper tracing in each givesthe drops issuing from the veins. Lower tracing—time in ten seconds. a. Normal. 25 drops in 100. b. Ringers solution saturated with carbon dioxide. 38 drops in 100. c. Normal again. 22 drops in 100. d. Carbon dioxide again. 33 drops in 100. the same effect as saturation with carbon dioxide,that is, an increase in rate of flow to 1*5 times its 52 INTRAVENOUS INJECTION former value (Fig. 18). These concentrations arephysiologically high as regards hydrogen-ion con-centration and amount to 1,000 times those possiblein acidosis. Of course, the local effect of the acidat the point where it is produced is greater thanwhen diluted in the blood, but it is the latter effectthat we are considering here. If a small quantityof acid is injected into a vein of the cat, dilatationof the intestinal vessels occurs (Fig. 19). We maynote that the effect of acid on t
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