. The Biochemical journal, 1917. Biochemistry. 358 J. C. DRUMMOND It will be seen from a summary of these results that there is general agree- ment in regarding tryptophan, cystine and arginine or histidine as indispens- able dietary components, but that opinion is divided regarding the value of lysine and the amino-acids containing the benzene nucleus. The application of these results to the determination of the influence of individual amino-acids upon tumour growth was carried out in a similar manner to that employed in the study of the nutrition of the normal animal by Abderhalden and by Ho
. The Biochemical journal, 1917. Biochemistry. 358 J. C. DRUMMOND It will be seen from a summary of these results that there is general agree- ment in regarding tryptophan, cystine and arginine or histidine as indispens- able dietary components, but that opinion is divided regarding the value of lysine and the amino-acids containing the benzene nucleus. The application of these results to the determination of the influence of individual amino-acids upon tumour growth was carried out in a similar manner to that employed in the study of the nutrition of the normal animal by Abderhalden and by Hopkins. Two amino-acid mixtures were prepared Rat 12 19 Days 26 33 ⢠40 f Remarks Weight or Wcijjht ul' nitâtuinuur Change in wcijfht oC host B- Cliange Height â ot host per I K tumour (S ⢠⢠⢠Tumour somewhal tirnt and fibrous. Animal very emaciated 85 675 -35 5 9 ⢠⢠f 0 f ditto 80 560 -18 0 6 ⢠f t ⢠- Tumour well vasf'ulartfied, Arm and slow glowing Animal \ery i^ntaciated 80 670 -33 0 cS « » f ⢠â - ditto 35 465 -15 5 9 ⢠f f - - Killed and devoured '^.I(; - - - Averiige 7-0 - -25 5 -3 6 120 < 100- s. v. V â Weight [normal Ral " Rat - Tumour ⢠,, Ral + Tumour (â I monttH Chart 18. Tumour development, and growth curves of normal and tumour-bearing rats upon acid-hydrolyscd mcat-protcin diet. Tumour S/lllc. from hydrolysed muscle protein, the one containing all the amino-acids excepting tryptophan, whilst from the other all the amino-acids which are precipitated by phosphotungstic acid had been removed. A commercial sample of completely hydrolysed meat-protein ("erepton") containing tryptophan, and prepared according to the method of Abderhalden, served as a control to these Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Bioc
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