Twentieth century practice; an international encyclopedia of modern medical science by leading authorities of Europe and America . cur in the appear-ance of the nucleus, and in some cases I have been struck by thefact that the chromatin of the nucleus of some was distiuctlj lessmarked than in the normal blood and much more irregularly dis-tributed, while in others the normal appearance or even abnormallyabundant chromatin was observed. The neutrophilic granulescharacteristic of these cells in the normal blood may be present as inhealth, but all observers who have studied the blood of leukaemia
Twentieth century practice; an international encyclopedia of modern medical science by leading authorities of Europe and America . cur in the appear-ance of the nucleus, and in some cases I have been struck by thefact that the chromatin of the nucleus of some was distiuctlj lessmarked than in the normal blood and much more irregularly dis-tributed, while in others the normal appearance or even abnormallyabundant chromatin was observed. The neutrophilic granulescharacteristic of these cells in the normal blood may be present as inhealth, but all observers who have studied the blood of leukaemiahave noted the occasional entire absence of the granules. More com-monly the granules are less abundant and less sharply defined thanin normal blood. Sometimes oxyphilic granules are observed. Thesupervention of some form of infection may cause a reduction in thetotal number of leucocytes in the blood, as has already been ob-served, and at the same time the polynuclear forms may becomerelatively more abundant. The same change occurs when thenumber of leucocvtes diminishes under treatment. 422 STENGEL—DISEASES OP THE In studying the blood of leuksemic cases the nuclear alterationsare always striking and in particular the tendency to a decreasedrichness in chromatin. The peculiar pale and often irregular nucleusof the myelocytes is most conspicuous, but in all of the forms similarchanges are noticeable. Very recently Gumprecht has called par-ticular attention to this and holds that it is an evidence of transfor-mation of the nuclein compounds of the nucleus into xanthin —Important facts in the pathology of the diseasehave been added by the discovery of leucocytes presenting karyoki- nesis. These were first demonstratedby riemming, but were subsequentlyobserved by Arnold, Hayem, Spronk,Miiller, Wertheim, and others. Usu-ally the number of leucocytes ofthis character is extremely small, andFlemming states that he saw but oneamong a number of thousand
Size: 1549px × 1612px
Photo credit: © The Reading Room / Alamy / Afripics
License: Licensed
Model Released: No
Keywords: ., bookcentury1800, bookdecade189, booksubjectmedicine, bookyear1895
