. The Biochemical journal, 1906. Biochemistry. ACTION OF ETHYL CHLORIDE, BROMIDE, ETC. 337 experiments with the different drugs named, the vagus in the neck (cut or uncut) has been stimulated when the animal was fully under the influence of the anaesthetic, never has there been any diminution of the usual inhibitory effect. Often, on the contrary, the cff^ect of vagus stimulation seems to have been exaggerated. (See Figs, i and 5). This point has been further investigated upon the frog's heart recorded by the suspension methods. In two or three experiments it has been impossible to abolish the
. The Biochemical journal, 1906. Biochemistry. ACTION OF ETHYL CHLORIDE, BROMIDE, ETC. 337 experiments with the different drugs named, the vagus in the neck (cut or uncut) has been stimulated when the animal was fully under the influence of the anaesthetic, never has there been any diminution of the usual inhibitory effect. Often, on the contrary, the cff^ect of vagus stimulation seems to have been exaggerated. (See Figs, i and 5). This point has been further investigated upon the frog's heart recorded by the suspension methods. In two or three experiments it has been impossible to abolish the vagus action on either pre- or post-ganglionic fibres with ethyl bromide. Moreover there cannot be any action on the ganglion cells since the effect can be induced after pouring the drug upon the Fig. 10. Intestine, respiration, carotid blood pressure. Dog, 9*6 K, —morphia. Ethyl chloride. Shows diminution in extent and in frequency of respiration with recovery. Mode of Action of the Drugs The fall of blood-pressure, which always occurs, except perhaps with minimal doses, seems to be due to diminished force and frequency of the heart-beat. On the other hand the slight temporary rise with small doses, or as a first stage with larger doses, is due to a preliminary increase in force and frequency of the Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Biochemical Society (Great Britain); University of Liverpool. Biochemical Dept. London [etc. ] Cambridge University Press
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