Illustration of the British biologist John Sulston (1942-2018). Sulston is best known for his work with the nematode worm Caenorhabditis elegans. He p
Illustration of the British biologist John Sulston (1942-2018). Sulston is best known for his work with the nematode worm Caenorhabditis elegans. He played a central role of the sequencing of its genome and used it to study programmed cell death, or apoptosis. Apoptosis is a highly regulated process that is vital for foetal and organ development and to remove damaged or diseased cells. Sulston mapped a complete cell lineage for C. elegans and showed that apoptosis was a normal and highly regulated part of development. He also identified the first mutations in genes involved in the process. Sulston was awarded a share of the 2002 Nobel Prize in Physiology or Medicine for this work along with Sydney Brenner and H Robert Horvitz. He was Director of the Sanger Institute, Cambridge, UK, from 1992-2000, during which time the whole genome sequence of C. elegans and a 'rough draft' of the complete human genome were published.
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