American journal of pharmacy . intained under sterile conditions asabove. Drug F2190: Date. Time. 9-16-19 At once AfterAfter 9-22-19 After 9-24-19 After 9-29-19 After 10- 8-19 After 10-18-19 After 10- 23-19 After 11- 10-19 After 12- 17-19 After Activity, %. % Deterioration. 30 hours54 hours6 days8 days13 days22 days32 days37 days53 days92 days 1-26-20 After 132 days The above work was repeated at room temperature. 105 0 95 10 95 10 85 19 85 19 80 24 70 33 65 38 60 43 55 48 45 57 40 61 Date. Time. 10-14-19 After 24 hours 10-17-19 After 4 days 10- 23-19 After 10 days 11- 11-19 After 28 days 12-
American journal of pharmacy . intained under sterile conditions asabove. Drug F2190: Date. Time. 9-16-19 At once AfterAfter 9-22-19 After 9-24-19 After 9-29-19 After 10- 8-19 After 10-18-19 After 10- 23-19 After 11- 10-19 After 12- 17-19 After Activity, %. % Deterioration. 30 hours54 hours6 days8 days13 days22 days32 days37 days53 days92 days 1-26-20 After 132 days The above work was repeated at room temperature. 105 0 95 10 95 10 85 19 85 19 80 24 70 33 65 38 60 43 55 48 45 57 40 61 Date. Time. 10-14-19 After 24 hours 10-17-19 After 4 days 10- 23-19 After 10 days 11- 11-19 After 28 days 12- 17-19 After 64 days 1-28-20 After 106 days Activity, 1059080726040 % Deterioration,O 2431 4361 Plotting these curves over to 100 per cent, basis as a startingpoint in each case. 110 Rate of Deterioration of Infusions of Digitalis 90 Q tt 80 Q (0 fco 540u O JO0: 20 62) WHICH MOLDED IN ABOUT 2.^ DAYS (ROOMTfMpJ ROOM TEMP STER/LE WAR n WEATHER(.C) IO°C STERILE (d) ROOM TEt^FERATURE. COOL VYEATHER t*^) 15% infusion: cool \0 l^ 14 Ife 16 20 ?Z 2A 28 iO i,2 34 .it ^8 Time in Days 400 Stability of Digitalis Leaf Extracts. [^^- ^^f^vl^i^^: From these curves it is shown that four infusions passed a pointof 20 per cent, deterioration as follows:(a) Which molded in about 2V2 days.(6) At room temperature and warm weather in 3-4 days.{c) At 10° C. in 8 days. id) At room temperature in cooler weather; 7 days. C. Observations on Deterioration of Per Cent. Infusion {U. S. P.).—We purposely began this investigation with 10 per cent, infusionsbecause it was found that in using per cent, solutions that con-siderable concentration was required before injection, i. e., percent, solutions are poorly absorbed. It might be objected that thisconcentration rather than the storage produced deterioration. Expt. I {1-1^-20).—A fresh per cent, infusion U. S. P. wasprepared (F2190), and two aliquots of 100 Cc. were concentrated toexactly 15 Cc. thus making the final concentrat
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Keywords: ., bookcentury1800, bookidamerica, booksubjectpharmacy, bookyear1835
