Nervous and mental diseases . , Feb. 1, 1902. 3 Berlin, klin. Wochens., 1899. 4 Deut. Zeit. f. Nervenheilk., Nov., 1906, Bd. 31. 5 Deutsch. Zeitschr., Bd. 3?, page 175. 6 Oppenheim, Myesthenische Paralyse, Berlin, 1901. 164 DISEASES OF THE CRANIAL NERVES. case showed regular muscular exhaustion under electrical stimulus,and this has been generally found in other In some instancesthere is a tendency to improve and to relapse, as in the case of Collins,in which case the special senses of sight and hearing also showed rapidexhaustion. E. F. Buzzard,2 in a study of five cases, noted decide


Nervous and mental diseases . , Feb. 1, 1902. 3 Berlin, klin. Wochens., 1899. 4 Deut. Zeit. f. Nervenheilk., Nov., 1906, Bd. 31. 5 Deutsch. Zeitschr., Bd. 3?, page 175. 6 Oppenheim, Myesthenische Paralyse, Berlin, 1901. 164 DISEASES OF THE CRANIAL NERVES. case showed regular muscular exhaustion under electrical stimulus,and this has been generally found in other In some instancesthere is a tendency to improve and to relapse, as in the case of Collins,in which case the special senses of sight and hearing also showed rapidexhaustion. E. F. Buzzard,2 in a study of five cases, noted decidedsensory disturbances of a tabetic distribution in one, and fleeting areasof paresthesia and analgesia in others. Localized atrophies are also pos-sible and certain changes in the muscle fibers indicate early amyotrophicconditions. In all his cases various muscles and organs showed lymph-ocytic infiltration, though thymus glandular anomalies were not alwayspresent. Mental disturbance of a mild order has also been Fig. 65.—Myasthenia gravis in an advanced case. 1, Mask-like, expressionless face, drooping eye-lids, etc.; 2, forced attempt to smile vigorously; 3, forced attempt to close eyes firuilv and to protrudetongue vigorously : it passed the lips with difficulty ; the eyeballs were hardly covered. The condition is marked essentially by asthenia, affecting particularlythe motor apparatus. The prognosis is grave, as a fair proportion ofthe cases terminate fatally through asphyxia. In the treatment, rest isadvised with correction of any toxic or septic factor that may be dis-covered. The free administration of strychnia is probably harmful. Ihave seen the tendon reflexes repeatedly disappear under its use by thehypodermatic method, returning regularly upon its withdrawal. 1 Buzzard, British Med. Jour., March 3, 1900. 2 Brain, Winter, 1905. PAET III. DISEASES OF THE BRAIX PROPER. CHAPTER CEREBRAL CORTEX—LOCALIZATION, General Considerations.—The subject


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