. The chemistry of the injured cell. Cytochemistry; Pathology, Cellular. Shock and Related Phenomena 139 Furthermore, animals the phagocytic properties of whose RES has been diminished by blockage show increased sensitivity to both shock and endotoxin (Beeson, 1947) . Similarly, rats and rabbits suffering from haemorrhagic shock exhibit striking depression of the phagocytic clearance properties of the RES (Zweifach and Bena- cerraf, 1958). On the other hand, stimulation of these activities of the RES by injections of non-toxic colloids induces resistance to shock in rats. In addition, in shock
. The chemistry of the injured cell. Cytochemistry; Pathology, Cellular. Shock and Related Phenomena 139 Furthermore, animals the phagocytic properties of whose RES has been diminished by blockage show increased sensitivity to both shock and endotoxin (Beeson, 1947) . Similarly, rats and rabbits suffering from haemorrhagic shock exhibit striking depression of the phagocytic clearance properties of the RES (Zweifach and Bena- cerraf, 1958). On the other hand, stimulation of these activities of the RES by injections of non-toxic colloids induces resistance to shock in rats. In addition, in shocked animals the RES cannot be stimulated in this fashion and RES blockade induced experiment- ally in shocked animals lasts for three to five days as opposed to eight to twelve hours in normal animals. The precise role of the RES in shock remains uncertain. It is known, however, that RES blockade induces hypersensitivity of SHOCK-INDUCING INJURY Increased Histamine S j n t h e s i s. Release of Endogenous Toxins [ Polysaccharides. M, Proteases] DECOMPENSATION OF SMALL BLOOD VESSELS Fig. 11. Some Suggested Factors in the Mechanism of Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Cameron, Roy, Sir, 1899-1967; Spector, W. G. (Walter Graham). Springfield, Ill. , Thomas
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