A reference handbook of the medical sciences, embracing the entire range of scientific and practical medicine and allied science . concretions in adipose tissue).As the result of fat-splitting (fatty degeneration orfat necrosis) the free fatty acids combine with cal-cium to form calcium soaps (combinations of fattyacid, calcium, and protein). Later the fatty acidsare replaced by carbonic or phosphoric acid. Towhat extent this method of formation occurs in theother forms of calcification is not yet certain. Klotz and others hold that the first step in the formationof pathological calcification
A reference handbook of the medical sciences, embracing the entire range of scientific and practical medicine and allied science . concretions in adipose tissue).As the result of fat-splitting (fatty degeneration orfat necrosis) the free fatty acids combine with cal-cium to form calcium soaps (combinations of fattyacid, calcium, and protein). Later the fatty acidsare replaced by carbonic or phosphoric acid. Towhat extent this method of formation occurs in theother forms of calcification is not yet certain. Klotz and others hold that the first step in the formationof pathological calcification is the production ofcalcium soaps that afterward become changed intophosphates and carbonates. In support of liis viewlie showed experimentally that collodion sacs con-taining fat or fatty acid into the peritonealcavity of a rabbit would in a few days contain amountsof calcium far in excess of that found in the body-fluids of the animal. Calcium percolating into becomes fixed. Wells opposes this view andholds that there is no essential difference betweenthe processes of ossification and pathological calci-. •;- ^^ ?^ ^^ m Fig. 1185.—Calci6cation of Kidney in a Case of LeukemiaTreated for a Long Period with Rontgen-ray Irradiation. Lowpower. fication. The close relationship between fatty de-generation and calcification may be taken as anargument in favor of Klotzs views, but the problemmust still be regarded as unsettled. At the presenttime we do not even know the nature of the calciumcombinations in the blood, and until we know moreconcerning the combinations of calcium and protein,or the disintegration compounds of the latter, andtheir occurrence in calcified areas, we cannot hopeto understand the nature of calcification. The evidence in favor of a physical deposition ofthe lime-salts is also unsatisfactory. It is true thatsterilized cartilage exhibits a specific absorptionaffinity for lime-salts similar to that shown by gelatindisks toward other cry
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