. Radium . in car-cinoma or sarcoma tissue under influence of radium and the Roentgenrays are observed in the tumor cells themselves, and are manifested bythe vacuolation of the protoplasm, pyknosis of nuclei, kar\-olysis, andultimately complete necrosis of the cell. These cellular changes areaccompanied by a round cell infiltration which replaces the destroyedcancer cells. Subsequently this round cell infiltration is changed intodense sclerotic connective tissue poor in blood vessels. This connectivetissue formation may become very extensive, surround islands of cancercells, and assist in the
. Radium . in car-cinoma or sarcoma tissue under influence of radium and the Roentgenrays are observed in the tumor cells themselves, and are manifested bythe vacuolation of the protoplasm, pyknosis of nuclei, kar\-olysis, andultimately complete necrosis of the cell. These cellular changes areaccompanied by a round cell infiltration which replaces the destroyedcancer cells. Subsequently this round cell infiltration is changed intodense sclerotic connective tissue poor in blood vessels. This connectivetissue formation may become very extensive, surround islands of cancercells, and assist in the destruction of the latter. Indeed, this new con-nective tissue formation is the most generally observed morphologicchange in the tumor. Some observers even maintain that this connectivetissue formation is the only direct effect of radiation, while the destruc-tion of the tumor cells is secondary and is due to lack of nutrition. How-ever, this opinion is not borne out by facts. The first morphologic change. Fig. 1 (Case 1).—Scirrhus carcinoma of the breast. noted is always the destruction of the tumor cells, and the connectivetissue appears only subsequently. Moreover, in certain conditions—for nstance, rodent ulcer of the skin—the epithelioma cells disappear andthe ulcerated area is covered with skin epithelium without any formationof connective tissue. The assumption, on the other hand, that the for-mation of connective tissue is secondary to the accumulation of deadtumor cells and is analogous to foi-mation of connective tissue aroundforeign bodies and particles of dead matter is also hardly tenable. Were his connective tissue formed only by the stimulus of the dead tumorcells, then the radiations would dissolve it subsequently as easily as itdissolves a keloid, for instance. However, this does not take place, andthe amount of the peculiar sclerotic connective tissue usually increaseswith subsequent radiations. 24 Radium A case of carcinoma of the sigmoid with metastat
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Keywords: ., bookauthorcameronw, bookcentury1900, bookdecade1910, bookyear1913
