. Endocrinology. A/ \ / V I I I v\ V .v^r. 27 28 29 30 5 4. 5 €> 7 8 To+ai N. Ciuaf ininc N. RAITII 317 A review of the results of many observers leads us to theconclusion that in disease the creatinine output is not constant,as it is in health, but in no case have we found the correlationbetween the creatinine and total nitrogen so great as in the eases 14 312 O as 8 Q? 7 055 , ^%^ ,anc- 4-. 13 -<5 16 7 ifeflpr^ i 567 ^ ^ • Tofal N-Crca+irsirsc-^- here reported. Shaffer (9) has shown that a low excretion ofcreatinine is found in many pathological conditions and thatt
. Endocrinology. A/ \ / V I I I v\ V .v^r. 27 28 29 30 5 4. 5 €> 7 8 To+ai N. Ciuaf ininc N. RAITII 317 A review of the results of many observers leads us to theconclusion that in disease the creatinine output is not constant,as it is in health, but in no case have we found the correlationbetween the creatinine and total nitrogen so great as in the eases 14 312 O as 8 Q? 7 055 , ^%^ ,anc- 4-. 13 -<5 16 7 ifeflpr^ i 567 ^ ^ • Tofal N-Crca+irsirsc-^- here reported. Shaffer (9) has shown that a low excretion ofcreatinine is found in many pathological conditions and thatthe excretion of an abnormally small amount is not peculiar to 318 CREATININE AND NITROGEN ELIMINATION any one disease. In these two patients the creatinine coefficientis low, but this is to be expected because both were excessivly fat. Practically all investigators are agreed that the amount ofcreatinine excreted is an index of muscular efficiency. We haveno proof, however, that creatinine arises wholly in the muscles,but that it does arise there, in part at least, may be consideredproven. Experiments by Gottlieb and Stangassinger (10) appear toindicate that the formation of creatin and creatinine takes placein the glandular organs as well as in the muscles. Our own results seem to indicate that the pituitary body hassome controlling influence on creatinine excretion, either by con-trolling its rat
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Keywords: ., bookcentury1900, bookdecade1910, booksubjectendocrinology, bookye
