RNA INTERFERENCE
Interfering RNA (RNAi) - stage 2. In the cytoplasm of the cell-host, replication of the viral single-stranded RNA into double-stranded by RNA replicase (RNA dependent RNA polymerase). The replication of the RNA occurs for the negative-stranded RNA viruses. Interfering RNA is a mean for the cell to destroy the RNA parasites (viruses RNA, transposons). In the cytoplasm, proteins (Dicer, visible here in background, then RISC), associated to a fragment of RNA (RNA guide), link to the molecule of the virus RNA or transposon. The latter is then cut by the endonuclease activity of RISC (cleavage) then destroyed. The cell then eliminates all foreign RNA. RNA interference is currently under study to turn off individual gene expression (silencing) in the framework of the development of new therapies. See. images 1072907, 1073007, 1073107, 1073207, 1073307 and 1073407 for the detailed explanation of the RNA interference.
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