. Endocrinology. here can be pro-duced macro- and micro-scopic changes of the inclosed testes ofthe same kind as we find them in natural cryptorchism. An in-closed testis was ^quickly reduced in size, sometimes after 3 arms. Foitschr. f. naturwiss., Forschung xl., 5, 1022 ;und d. Steinachsen operation. Wien., lf»22. 286 ENDOCRINOLOGY OF SEXUAL GLANDS months, to one-third and after a longer time to one-tenth of theweight of the contralateral, normal testis. It turned out that this experimental teehniijue was much(|uicker and more certain in its effect than the vasoligation, inexperiment
. Endocrinology. here can be pro-duced macro- and micro-scopic changes of the inclosed testes ofthe same kind as we find them in natural cryptorchism. An in-closed testis was ^quickly reduced in size, sometimes after 3 arms. Foitschr. f. naturwiss., Forschung xl., 5, 1022 ;und d. Steinachsen operation. Wien., lf»22. 286 ENDOCRINOLOGY OF SEXUAL GLANDS months, to one-third and after a longer time to one-tenth of theweight of the contralateral, normal testis. It turned out that this experimental teehniijue was much(|uicker and more certain in its effect than the vasoligation, inexperiments on the question of the hormone tissues of the testis. The existing atrophy of the spermatic canals was accom-panied by a certain slighter or stronger hypertrophy of Leydigcells; this was most pronounced after occlusion in full-grownanimals; less after occlusion in infantile animals, and seemed,besides, to increase with the duration of the occlusions and de-gree of canal atrophy. Fig. 11 is given as an Fig. 11Guinea-pig No. 124. Experimental cryptorcliism. produced onan infantile animal by an 11 montlis bilateral occlusion of theinguinal canal. Microscopic photograph shows a general view oftestis : the strongly atrophic canals, surrounded by enormously aug-mented Leydig cells. Fig. 12 of normal guinea-pig testis, magnifiedto the same degree, will serve for comparison. I have succeeded experimentally (through one-sided occlusiocanalis inguinalis combined with contralateral castration) in 3cases in producing phenomena which can be interpreted as acompensatory hypertrophy which, judged from everything, isdue alone to the Leydig cells. All of the groups of experiments corroborate, to the greatestextent, the theory that the Leydig cells are substantially the mostimportant for production of the male sexual hormones. Theseolder experiments from 1914 to 1917 I have taken up later. Asingle preliminary result of the new experiments I shall merely SAND 287 mention on account o
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