. Radium, X rays and the living cell. which appears intact. This shreddy material stains with aciddyes, and under a high power is seen to have a finely granularstructure. As regards the nuclei above mentioned, the nuclearmembrane is seen to be well defined, and the chromatin is evenlydistributed in the form of extremely fine granules. One nucleolusis present, darkly stained and relatively large. In what may be termed the penultimate stage of destruction,the lumina of the tubules are largely occupied by necrotic materialand fatty masses, some of which are of considerable size. Theshreddy materi
. Radium, X rays and the living cell. which appears intact. This shreddy material stains with aciddyes, and under a high power is seen to have a finely granularstructure. As regards the nuclei above mentioned, the nuclearmembrane is seen to be well defined, and the chromatin is evenlydistributed in the form of extremely fine granules. One nucleolusis present, darkly stained and relatively large. In what may be termed the penultimate stage of destruction,the lumina of the tubules are largely occupied by necrotic materialand fatty masses, some of which are of considerable size. Theshreddy material which preponderates in the ultimate stage isalso present here, though in smaller amount. Some of the mostcharacteristic changes are illustrated in Figs. 40 and 41. Changes produced in the different elements of the testis. If 242 THE GENERATIVE SYSTEM a testis is removed and examined immediately after exposure,no changes whatever are observed. If, however, 24 hours areallowed to elapse between exposure and removal, definite changes. Fig. 40.—Seminiferous tubule thirteen days after the application of X rays. All theseminal cells have disappeared. Hxternally the basement membrane is seen. Distributedwithin the tubule are numerous nuclei of cells of Sertoli, the cytoplasm of which foniis acoarse framework, within the meshes of which fatty masses, more or less darkly stainedwith osniic acid, ore sparsely scattered. No definite lumen is present in the tubule. Wakelin Marratt ai\d .Arnold, Archiv fiir Zellforschung, vol. 7. p- -A-- 1911. THE GENERATIVE SYSTEM 243 At the end of a week
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