. The effects of inanition and malnutrition upon growth and structure. Starvation; Nutrition. EFFECTS ON THE SKELETON 151 The skeletal changes in human adult scurvy have been described recently by Aschoff and Koch ('19), Bierich ('19) and Comrie ('20). In children, scurvy was long confused with rickets. Infantile scurvy was first clearly demonstrated by Barlow ('83, '94) and is therefore commonly known as Barlow's disease. At that time but little was known of the essential histological changes in the skeleton during infantile scurvy, the details of which have since been thoroughly investigated
. The effects of inanition and malnutrition upon growth and structure. Starvation; Nutrition. EFFECTS ON THE SKELETON 151 The skeletal changes in human adult scurvy have been described recently by Aschoff and Koch ('19), Bierich ('19) and Comrie ('20). In children, scurvy was long confused with rickets. Infantile scurvy was first clearly demonstrated by Barlow ('83, '94) and is therefore commonly known as Barlow's disease. At that time but little was known of the essential histological changes in the skeleton during infantile scurvy, the details of which have since been thoroughly investigated by numerous workers. Naegeli ('97) was the first to give a detailed description of these changes, which have been confirmed and extended by Schmorl ('99, '01, '07), Schodel and Nauwerk ('00), Jacobsthal ('00), Looser ('05), Erdheim ('18), and others. Fraenkel ('04, '06, 08,) has studied especially the skeletal changes as shown by the Rontgen-rays, including the so-called "white ; The pathology and pathogenesis of scurvy have also been .c â Jfe* **W-2*ff?5£??. Pig. 55.âFrom a photograph of a portion of a section through the costochondral joint of a normal guinea pig; body weight 236 g. C, costal cartilage; Z, zone of enchondral ossification (bony and calcified cartilaginous trabeculae, and invading marrow); M, costal marrow; D, bone of costal diaphysis; P, costal periosteum and adjacent intercostal muscle. Zenker fixation; hematoxylin-eosin stain. X40. (Preparation by Everett Rowles.) reviewed by Vincent ('04), Lesage I'n), Schmidt ('21) and especially by Hess ('20). Hojer's ('24) recent monograph is excellent. The gross skeletal lesions include osteoporosis, with fragility and thinning of the cortex in the shaft of the long bones, and frequent occurrence of fractures in severe cases. Enlargement of the costochondral joints occurs, and has frequently been mistaken for rickets (cf. Hess '20; Hess and Unger '20). The general hemorrhagic condition in scurvy is
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