. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. 476 ADVENTURES IN RADIOISOTOPE RESEARCH reaction between inorganic phosphate ions and the hydrolysable esters is a very fast process. That the inorganic P present in the corpuscles does not reach exchange equilibrium with the plasma phosphate in the course of a few hours is due to the fact that a large part of the active phosphate ions are incorporated into the organic compounds of the corpuscles, while simultaneously non-active phosphate ions are freed to take place of the active ones and "dilute" the active
. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. 476 ADVENTURES IN RADIOISOTOPE RESEARCH reaction between inorganic phosphate ions and the hydrolysable esters is a very fast process. That the inorganic P present in the corpuscles does not reach exchange equilibrium with the plasma phosphate in the course of a few hours is due to the fact that a large part of the active phosphate ions are incorporated into the organic compounds of the corpuscles, while simultaneously non-active phosphate ions are freed to take place of the active ones and "dilute" the active inorganic phosphate. Fig. 1. Ilatio of the specific activities of the total acid- soluble phosphate and the inorganic phosphate present in the corpuscles. X = Rabbit G. O = Rabbit H. which penetrated into the corpuscles, diminishing thus the specific activity of the corpuscle inorganic P. If the whole ester-phosphorus could exchange with the inorganic P, the activity-ratio should finally reach a value (indicated by the g dotted line). It is clear that the hmiting value of--^ is much lower, which is due to the presence of an organic phosphorus fraction in the corpuscles exchanging at a slow rate. PENETRION OF PLASMA HPO4 INTO CORPUSCLES We may obtain information as to the rate of penetration of the HPO from the plasma into the corpuscles by comparing, after a lapse of time, the specific activities of the plasma inorganic P and that of the total acid-soluble P present in the corpuscles. An alternative method would be to compare the specific activities of the plasma inorganic P and the. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Hevesy, Georg von, 1885-1966. New York, Pergamon Press
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