A patient with diabetes suffering with a septic foot. Unregulated hyperglycaemia (high blood glucose levels) leads to non-enzymic glycation of protein
A patient with diabetes suffering with a septic foot. Unregulated hyperglycaemia (high blood glucose levels) leads to non-enzymic glycation of proteins in the walls of the blood vessels. This compromises the basement membrane of the smaller arterioles and capillaries, enabling the movement of proteins across it. As a result, the colloid pressure of the tissues in the periphery is increased and interstitial fluid accumulates. Peripheral neuropathy frequently occurs due to the reduced oxygen delivery to the nerves as a consequence of damaged capillaries. This loss of sensation results in an increase in accumulated foot trauma from abnormal weight-bearing, leading to the development of callouses; and later ulcers. Diabetics are already more susceptible to bacterial infections as high blood glucose inhibits some components of the immune system. Coupled with a loss of the epidermis and glucose-rich interstitial fluid, the diabetic foot provides the perfect medium for bacterial growth.
Size: 5157px × 3425px
Photo credit: © Medicimage Education / Alamy / Afripics
License: Licensed
Model Released: No
Keywords: amputate, amputation, amputee, copy, diabetes, diabetic, disease, diseases, extremities, foot, gangrene, infection, limb, master, model, peripheral, released, septic, toe, vasculitis
