. The Biochemical journal, 1917. Biochemistry. 354 J. C. DRUMMOND The influence of these dietaries upon the growth of the normal rats supports the work of Totani, in that the addition of tryptophan greatly raises the nutritive value of the gelatin diet, whereas the further addition of tyrosine has little if any such effect. The retarding influence upon tumour growth which is exerted by the amino-acid deficiencies of the gelatin ration is well marked. As in other similar cases this is accompanied by a severe drop in the body-weight of the host. Rat Days 12 19 26 33 Remarks Weight of tumoui- Wei
. The Biochemical journal, 1917. Biochemistry. 354 J. C. DRUMMOND The influence of these dietaries upon the growth of the normal rats supports the work of Totani, in that the addition of tryptophan greatly raises the nutritive value of the gelatin diet, whereas the further addition of tyrosine has little if any such effect. The retarding influence upon tumour growth which is exerted by the amino-acid deficiencies of the gelatin ration is well marked. As in other similar cases this is accompanied by a severe drop in the body-weight of the host. Rat Days 12 19 26 33 Remarks Weight of tumoui- Weight of rat-tumour Change iii weight of rat Change weight of host per 1 g. tum<yir 9 d 6 6 9 ⢠â¢â¢ ' ⢠â¢â¢ * ⢠â¢â¢ Rat thin Tumour sliows slight central necrosis ditto ditto ditto J8 5 ISO 14 0 110 50 715 850 940 650 830 -20 5 -28 0 -16 0 -250 -7 0 Average 12 7 - -193 -152 140- 120- â IVe/gtit normal Rat. s \ â 'â Rat - Tumour Rst + Tumour s:-- \ (-/ months 40 I I } I 1 I g n ' I 1 I Chart 15. Tumour development, and growth curves of normal and tumour-bearing rats upon Gehatin diet, described in Chart 14, + 0-5 % tryptophan. Tumour >S/118a. When tryptophan has been added to the diet, tumour growth becomes normal, but there is a shght loss of weight upon the part of the host. The further addition of the missing tyrosine cannot be said appreciably to influence either tumour growth, or the sacrifiice of the tissues of the animal. The gelatin dietary to which the missing tryptophan and tyrosine have been added possesses a much lower nutritive value than the "normal". Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Biochemical Society (Great Britain); University of Liverpool. Biochemical Dept. London [etc. ] Cambridge University Press
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