Transactions of the Royal Society of Edinburgh . Experiment 49, and the slight effectof 142 grains twice repeated in Experiment 49a, show that this substance isuncertain in its action on the liver. Regarding its action on the intestinalglands, however, there was no uncertainty, for its purgative effect was pro-nounced in all the three experiments. Possibly, the sparing solubility of thesalt may render its absorption into the portal vein uncertain. The bile givenalong with the salt in Experiments 49 and 49a had probably nothing whatever PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 2
Transactions of the Royal Society of Edinburgh . Experiment 49, and the slight effectof 142 grains twice repeated in Experiment 49a, show that this substance isuncertain in its action on the liver. Regarding its action on the intestinalglands, however, there was no uncertainty, for its purgative effect was pro-nounced in all the three experiments. Possibly, the sparing solubility of thesalt may render its absorption into the portal vein uncertain. The bile givenalong with the salt in Experiments 49 and 49a had probably nothing whatever PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 201 to do with the result. The result of Experiment 49b completely supports DrWades opinion, that potassium sulphate is a cholagogue. Indeed, the amountof bile secreted per kilogramme of body-weight under its influence in thatexperiment was greater than in either of the experiments with sodium sulphate(48 and 48a). The apparent uncertainty, however, in the action of potassiumsulphate must not be lost sight of. Action of Sodium Bicarbonate. 15 05. The previously mentioned salts of sodium and potassium having all beenfound to have some action on the liver, it was determined to try the effect ofthe bicarbonates. Experiment 50. Dog that had fasted eighteen hours. Weight 16 3 kilo-grammes (fig. 50).—5 cc. water and 2 were injectedinto the duodenumat b (a needless pre-caution) ; 31 grainsof sodium bicarbon-ate in the same fluidwere injected at s, s,and s; and 124grains in 15 cc waterand 2 cc. bile wereinjected at s: 217grains being given in all. Only after the last dose did the secretion of bile begin to riseslightly. Necropsy.—The vascularity of the mucous membrane of the small intestinewas slightly increased. The viscus contained 60 cc. of a greenish mucousfluid. Experiment 50a.—Dog that had fasted eighteen hours. Weight 19 9 kilo-grammes (fig. 50a).—5 cc. of water and 2-5 cc. of bile were injected into theduodenum at b (a needless precaution), and the same fluid, wi
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