Studies from the laboratories of the Deptof Surgery . volucrum was strong enijugh tomaintain the .shape of the limb, and yet, at such a stage when theinvolucrum could be inverted, obliterating, as far as possible, the deadspace. In 1919, I attempted to reproduce osteomyelitis in dogs before thestudents of the third-year course in regional surgery at Columbia. Atthe suggestion of Dr. William C. Clarke of the rlepartment of surgery,through a drill hole in the cortex of the medullary canal of the humerus. 27 croton oil was introduced in glass capillary tube containers havin- theirends sealed with
Studies from the laboratories of the Deptof Surgery . volucrum was strong enijugh tomaintain the .shape of the limb, and yet, at such a stage when theinvolucrum could be inverted, obliterating, as far as possible, the deadspace. In 1919, I attempted to reproduce osteomyelitis in dogs before thestudents of the third-year course in regional surgery at Columbia. Atthe suggestion of Dr. William C. Clarke of the rlepartment of surgery,through a drill hole in the cortex of the medullary canal of the humerus. 27 croton oil was introduced in glass capillary tube containers havin- theirends sealed with agar-agar. The hole in the cortex was then peggedwith bone wax, and the soft parts and the skin were sutured. By thisprocedure, repair following the operative trauma was allowed toprogress before the croton oil was liberated from the capillarv tubeprobably by the solvent action of the cells and body fluids upon theagar-agar. As croton oil causes marked necrosis of the surroundin^rbone, we were able to produce a chemical osteomyelitis. A sequestrunT. Fig. 26 (Case 2).—Roentgenogram taken. Dec. 8, 1919, previous to opera-tion: Sq, sequestrum; /;;, involucrum ; S, separation zone. often from 5 to 10 cm. in length, and including the entire circumferenceof the shaft, frequently occurred (Figs. 11 to 17). This .sequestrumwas separated from a newly formed involucrum bv a zone of debrisand leukocytes; therefore, all the factors of an acute osteomvelitis werepresent with the exception probably of bacteria and their showed the sequestrum with an involucrum >urroun(ling it butseparated from it by a zone of pus. The cortical lione of sequestrumshowed absence of nuclei, and throughout its cancellous portion there 28 was a marked inhltration of leukocytes. The invulucruni consisted ofnewly formed subperiosteal bone. In the prolonged animal experiments roentgenologic studies showedthe gradual disappearance of the sequestrum so that at the end of twomonths it was imp
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