The Journal of biological chemistry . ght but definite fall in the level of blood sugar. Results of Experiments with Yeast Extract II. Chart II illustrates some results obtained with yeast extractII. Little or no hj^perglycemia w^as noted in this series of experi-ments. The experiment represented by Curve 2, Chart II, iscomplicated by the fact that a watery extract of fresh liver wasalso administered. The animal died in 47 hours. Rabbit 4 of J. B. Collip 517 this series died during the night before further blood sugar de-terminations were made. It will be noted that there is a con-siderable de
The Journal of biological chemistry . ght but definite fall in the level of blood sugar. Results of Experiments with Yeast Extract II. Chart II illustrates some results obtained with yeast extractII. Little or no hj^perglycemia w^as noted in this series of experi-ments. The experiment represented by Curve 2, Chart II, iscomplicated by the fact that a watery extract of fresh liver wasalso administered. The animal died in 47 hours. Rabbit 4 of J. B. Collip 517 this series died during the night before further blood sugar de-terminations were made. It will be noted that there is a con-siderable degree of variation in these experiments between thetime of injection and the time of most marked hypoglycemia. Results of Experiments ivith Yeast Extract III. Chart III illustrates the results of ten experiments in whichyeast extract III was administered. This series of experimentsfurnishes absolute proof of the existence in the extracts used of aprinciple which produces marked hypoglycemia in normal rabbits. enact in Yeast extract HI. Chart III. The occurrence of a definite hypoglycemia any time from 5 to65 hours after the administration of the extract is a very interestingphenomenon. An unusual result was noted in the case of Rabbit5 of this series. This animal which had been injected five timesin 4 hours showed a blood sugar of per cent, 7| hours afterthe last injection, hyperglycemia then followed and the animalbecame very weak and died 25 hours after the first 7 of this group was injected nine times over a period 518 Glucokinin of 20 hours. 5 hours after the last injection or 25 hours afterthe first, the animal had convulsions and died. The bloodtaken from the heart contained per cent of glucose. Results of Experiments with Yeast Extract IV. Chart rV illustrates some results in another series of experimentswith normal rabbits which were injected with yeast extract decidedly positive results will be noted here. Rabbit 5of this series rece
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Keywords: ., bookcentury1900, bookdecade1900, booksubjectbiochem, bookyear1905
