Organic and functional nervous diseases; a text-book of neurology . neurones themselves are singularlyfree from degeneration, even in the midst of sclerotic patches ; but oc-casionally cell bodies are found in various stages of degeneration whenthe plaque invades the gray matter, and fatty globules and granularcorpuscles, the result of this degeneration, are then scattered throughthe plaque. Even by Nissls method of staining there are found fewor no evidences of degeneration in the neurones. In some regions asimple atrophy of cells has been seen. The nerve fibres passingthrough the islet of sc
Organic and functional nervous diseases; a text-book of neurology . neurones themselves are singularlyfree from degeneration, even in the midst of sclerotic patches ; but oc-casionally cell bodies are found in various stages of degeneration whenthe plaque invades the gray matter, and fatty globules and granularcorpuscles, the result of this degeneration, are then scattered throughthe plaque. Even by Nissls method of staining there are found fewor no evidences of degeneration in the neurones. In some regions asimple atrophy of cells has been seen. The nerve fibres passingthrough the islet of sclerosis appear to be squeezed, their calibre beingreduced but their continuity preserved. The medullary sheath is re-duced materially, and here and there an axone is broken and degen-erated. The result of the degeneration of the myelin is seen in thepresence of fatty globules and waxy granules in the nerve patches. But,as a rule, the axones are preserved and lie naked, adjacent to oneanother, through the plaque, and appear as if the medullary sheath had Fig. Multiple sclerosis. Longitudinal section through a plaque in the spinal cord ; g, thickened neur-oglia ; I, empty spaces in the plaque ; z, large glia cells ; a, axis cylinder. (Schmaus-Sacki.) been dissolved off and absorbed. This peculiar appearance, first noticedby Charcot, has been confirmed by all subsequent observers and is char-acteristic of insular sclerosis. The preservation of the axone explainsthe absence of secondary degenerations in the various tracts. In a fewrecently reported cases, probably of very long duration, reliable ob-servers have reported secondary degenerations in both sensory andmotor tracts, but those are certainly the exception. The essential feature of the disease is therefore the production of a 678 MULTIPLE SCLEROSIS. peculiar neuroglia structure which is associated with a disappearanceof the myelin sheaths of nerve fibres. There are many theories inregard to this process, no one of whic
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Keywords: ., bookcentury1900, bookdecade1910, booksubjectnervoussystem, bookye
