Gynecology . sa. This theca membrane may become quite thick and wavy,like that of the granulosa. As in the true corpus luteum there is a vascu-larization and connective-tissue formation, so that the resulting picture is thesame as that of the corpus luteum, the essential difference being that the luteincells are of connective-tissue origin, and not epithelial. Follicle atresia is especially marked during pregnancy. During this period thereis no actual ovulation, so that most of the more mature follicles become atretic. 42 GYNECOLOGY It is said that during pregnancy there takes place in the the
Gynecology . sa. This theca membrane may become quite thick and wavy,like that of the granulosa. As in the true corpus luteum there is a vascu-larization and connective-tissue formation, so that the resulting picture is thesame as that of the corpus luteum, the essential difference being that the luteincells are of connective-tissue origin, and not epithelial. Follicle atresia is especially marked during pregnancy. During this period thereis no actual ovulation, so that most of the more mature follicles become atretic. 42 GYNECOLOGY It is said that during pregnancy there takes place in the theca lutein cellsof the atretic follicles not only hypertrophy but hyperplasia, and that thecells acquire more fat and lutein than is seen in the non-pregnant state. Inchorio-epithelioma and tubal gestation they sometimes form definite cysts whichlater disappear. In some species of animals the collections of theca lutein cells embedded inthe stroma form a constant picture. These masses of cells have been called. ri/vco^ Fig. 19.—Corpus power. At the top is the center of the corpus luteum, the edge seen being the edge of theblood-clot. Extending into this blood-clot are seen the pyramids formed of lutein cells, giving theedge of a corpus luteum its characteristic ruffled appearance. Between these two layers is a thinlayer of connective tissue. Below the layer of lutein cells—that is, around the outside of the corpusluteum—is the theca externa, which contains many blood-vessels. the interstitial gland, and correspond, as said above, to the lutein cells of theatretic follicles. They are thought by some to play a part in the manufactureof the internal secretion of the ovary. Two forms of follicle atresia are distinguished—the obliterating and thecystic. Cystic formation in the ovaries is, therefore, physiologic. The cysts,however, may grow to an abnormal size and become of pathologic significance.(See Retention Cysts.)
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