The treatment of syphilis . e of trivalent arsenic the effective dose can be in-troduced with much greater safety and, according to Ehrlich,the more powerful therapeutic action is due to the radical con-taining the trivalent arsenic, the importance of which was ren-dered apparent in experiments with trypanosomes and also tothe introduction of hydroxy radicals in the para position in themolecules, in which the amido radicals are in the ortho position,relatively to the hydroxy radicals. In the case of these doublering compounds, there is a double arsenic action due to the scis-sion of the salvar
The treatment of syphilis . e of trivalent arsenic the effective dose can be in-troduced with much greater safety and, according to Ehrlich,the more powerful therapeutic action is due to the radical con-taining the trivalent arsenic, the importance of which was ren-dered apparent in experiments with trypanosomes and also tothe introduction of hydroxy radicals in the para position in themolecules, in which the amido radicals are in the ortho position,relatively to the hydroxy radicals. In the case of these doublering compounds, there is a double arsenic action due to the scis-sion of the salvarsan (or neosalvarsan) molecule between the twoarsenic groups giving the action of two trivalent arsenic mole-cules. The chemical change which takes place in the blood isprobably represented by the following formulas: (Ernest Sie-burg—Zeitschr. physiol. client., Vol. 97, p. 53, 1916.) As V As NH2 As = 0 \y Protein combinationNH2 ^ ONa ONa OHAs = 0OH OH NH5 OH NH2 Amino oxy phenyl 2 amino 3 oxyarsenoxide phenyl arsenic acid. r nh2 or 3 oxyl phenyl arsinic acid V NH2 V OH OH amino phenols CHAPTER V INDICATIONS, CONTRAINDICATIONS AND EFFICIENCY OF AR- SPHENAM1NE Particular Indications for Arsphenamine Treatment It should not be accepted as a fixed rule that all cases of luesare to receive arsphenamine treatment. As elsewhere discussed,there are certain definite contraindications to the use of thearsenical preparations. It is generally accepted, however, thatparticular indications for the use of arsphenamine can be laiddown and it is, therefore, advised that the product be utilized in: i. All cases of early syphilis possessing distinctive symptoms. 2. In primary cases as an abortive agent. 3. In tertiary and latent cases with a positive Wassermann. 4. In tabes and paresis, congenital syphilis, malignant syphilis,painful periostitis and gummata. 5. In cases in which mercury cannot be used to advantage,when the patients become easily salivated or in which, after longcontinued mercur
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Keywords: ., bookcentury1900, bookdecade1920, booksubjectsyphilis, bookyear192
