. Pathogenic micro-organisms, including bacteria and Protozoa; a practical manual for students, physicians and health officers. vements. They are found only in the blood or blood organs,never in the secretions, and only during the fever, not in the intermis-sions, or at most singly at the beginning of, or for a short time after, anattack. When kept in blood serum, or a per cent, solution of sodiumchloride, they continue to exhibit active movements for a considerabletime. They may be preserved alive and active for many days in sealedtubes. They are killed (piickly at ()()° C., but they rema
. Pathogenic micro-organisms, including bacteria and Protozoa; a practical manual for students, physicians and health officers. vements. They are found only in the blood or blood organs,never in the secretions, and only during the fever, not in the intermis-sions, or at most singly at the beginning of, or for a short time after, anattack. When kept in blood serum, or a per cent, solution of sodiumchloride, they continue to exhibit active movements for a considerabletime. They may be preserved alive and active for many days in sealedtubes. They are killed (piickly at ()()° C., but they remain alive forsome time at 0° C. Unsuccessful eflorts to cultivate them in artificialculture media have l)een made from time to time. Koch has increase in the length of the sprilla and the formation of a tangledmass of filaments. Novy has finally succeeded in cultivating tliem incelloidin caj)sules placed in the peritoneum of rats. Pathogenesis.—In man, whether the disease is ac(|uire(l naturally orby artificial inoculation, the organism causes the following symptoms: 582 PATHOGENIC MICRO-ORGANISMS. Fig. 181. After a short period of incubation the temperature rises rapidly, re-mains high for five to seven days, and then returns to normal by seven days later there is another sudden rise of temperature,but this time the crisis occurs sooner. A second or third relapse mayoccur. The organisms increase in numbers rapidly in the blood fromthe beginning of the fever, large numbers often being found in everymicroscopic field. They began to disappear a short time before thecrisis, and immediately after the crisis it is practically impossible to findthem in the circulating blood. The mortality varies in differentepidemics from 2 to 10 per cent. When monkeys are inoculated with human blood containing thespirilla, they become sick about threeand a half days later, but show onlythe initial febrile attack or, at themost, an occasional short organisms ar
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