. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. Daniel E Koshland Jr contemporary rate of discovery, all possible inventions would be made in a few years. Today, the potentialities for biological research seem almost limitless. The con- quest of disease seems possible at the scientific level, even though it remains difficult at the economic level. Some of the applications of biological research which are clearly possible can reorient social relationships in ways that some regard as unethical. There may indeed be a widen- ing gap between what scientists could do and what t
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. Daniel E Koshland Jr contemporary rate of discovery, all possible inventions would be made in a few years. Today, the potentialities for biological research seem almost limitless. The con- quest of disease seems possible at the scientific level, even though it remains difficult at the economic level. Some of the applications of biological research which are clearly possible can reorient social relationships in ways that some regard as unethical. There may indeed be a widen- ing gap between what scientists could do and what they are allowed to do. Some of the future potentialities of biological research, and some of the ethical concerns which they may engender, will be discussed. The Molecular Basis of Differential Gene Transcription David Baltimore \\ 'hitehead Institute, Massachusetts Institute of Technology The antibody light chain gene is only transcribed in more mature B-lymphocytes. A protein factor, NF-kB, binding to the DNA of the gene's enhancer region ap- pears centrally responsible for this exquisite cell specific- ity of transcription. The factor exists in early preB-lym- phocytes, and other cells, as an inactive precursor in the cytoplasm. Activation of such cells with a mitogen or an active phorbolester causes the precursor to gain DNA binding activity, probably by release of an inhibitor, and to rapidly migrate to the nucleus. Further studies on this model differentiation system will be described. The long- term goal is to understand a discrete step of mammalian cellular differentiation. David Baltimore was born on March 7, 1938 in New York City. He received his with honors in chemistry from Swarthmore College in 1969. and his in biology from the Rockefeller University in 1964. In 1968 Baltimore served as an Associate Professor at MIT and became Professor of Biology there in 1972. He was appointed American Cancer Society Research Professor in 1973, and the following year h
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Keywords: ., bookauthorlilliefrankrat, booksubjectbiology, booksubjectzoology
