. Aspects of the origin of life. Life; Biochemistry; Biochemistry; Biogenesis. Protein Complexes as Biochemically Active Systems 187 Inhibition of proteolysis in the presence of DNA was also observed when heat-denatured egg albumin or casein were used as substrates of tryptic hydrolysis. The experimental results here reported show that enzymic processes in vitro can be affected by the presence in the reaction mixture of small quantities of substances such as hpids or nucleic acids, which are capable of interacting with the proteins taking part in the process. In the highly complex and mialtico
. Aspects of the origin of life. Life; Biochemistry; Biochemistry; Biogenesis. Protein Complexes as Biochemically Active Systems 187 Inhibition of proteolysis in the presence of DNA was also observed when heat-denatured egg albumin or casein were used as substrates of tryptic hydrolysis. The experimental results here reported show that enzymic processes in vitro can be affected by the presence in the reaction mixture of small quantities of substances such as hpids or nucleic acids, which are capable of interacting with the proteins taking part in the process. In the highly complex and mialticomponent system of the Uving cell such effects are evidentiy much more pronounced, and they are made still more complicated by the influence of the numerous interfaces between cellular organoids. ^ 40. Fig. 7. The kinetic curves for the proteolysis of serum albumin by trypsin at various DNA/substrate ratios (see text). The author is of the opinion that the formation of complexes by primordial proteins with one another and with other organic substances could have given rise to an enormous variety of compounds and chemical processes which, in the course of subsequent evolution, could have produced various conjugated proteins possessing specific biochemical fimctions, and could have engendered the whole set of enzymic processes essential to Hfe. The author wishes to acknowledge the participation of V. Z. Baranova, M. I. Bystrova and G. F. Ivashchenko in the experimental work. REFERENCES 1. A. I. Oparin, The Origin of Life on Earth. 3rd. ed. Izd. Akad. Nauk , Moscow, 1957. 2. D. F. Waugh, Advanc. Protein Chem., 9, 326, 1954. 3. O. P. Chepinoga, Nucleic Acids and Their Biological Significance. Izd. Akad. Nauk , Kiev, 1956. 4. E. Chargaff, M. Ziff & D. H. Moore, J. biol. Chem., 139, 383, Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustratio
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