. Radium, X rays and the living cell. e radiation is the destmction of lymphoidtissue in every region of the body ; this process appears to bequite independent of the subsequent cell destruction that occursin the spleen pulp and bone-marrow. The rapidity with which the changes in the lymphoid tissueoccur render it most probable that the effect is indeed a directone, and that this particular kind of cell is among the most SPLEEN 20T vulnerable to the X rays. Heineke was of the opinion that theywere of all cells the most vulnerable ; but it is a question whetherthis might not be said of certain
. Radium, X rays and the living cell. e radiation is the destmction of lymphoidtissue in every region of the body ; this process appears to bequite independent of the subsequent cell destruction that occursin the spleen pulp and bone-marrow. The rapidity with which the changes in the lymphoid tissueoccur render it most probable that the effect is indeed a directone, and that this particular kind of cell is among the most SPLEEN 20T vulnerable to the X rays. Heineke was of the opinion that theywere of all cells the most vulnerable ; but it is a question whetherthis might not be said of certain of the cells of the testicle, or ofsome varieties of new growths. The various stages in the destruction of h^mphoid tissue werestudied by Heineke in detail, and the sequence of events maybe briefly indicated as follows. In the first two hours of irradia-tion no histological changes are recognisable, but shortly after-wards (2^-3 hours) the nuclei of the lymphocytes suddenlydisappear, and there is a liberation of chromatin, which then. Fig. 32.—Cat exposed to X rays for 5 hours, killed four hours later. Section through the intestinal follicle. A great reduction in the number of lymphocytes,between which are numerous spheres of chromatin. Mitteihing aus den Grcnzgebielen der Medizin u. Chirurgie (14), 1905. collects into a number of small spheres—this action appears tostart in the more central parts of the spleen, and to proceedgradually to the peripheral portions ; with the onset of destructionof the lymphocytes, phagocytes make their appearance andgradually clear the tissue of the disintegrated cells. During thisprocess certain cells of an epithelioid character make their wayinto the follicles, which are being depleted of their normallymphocyte content. These cells are 3 or 4 times as large asthe lymphocytes, and have a strongly eosinophile protoplasm ;they go through various grouping formations, resembling at times cancroid pearls, and at certain stages are the most con- 2
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Keywords: ., bookcentury1900, bookdecade1910, bookpublisherlondo, bookyear1915
