. Ciba Foundation Symposium on Transplantation. Transplantation of organs, tissues, etc. THE FACTOR OF IMMUNIZATION 203 different loci, which fact might reflect that immunological reactivity is more essential for the organism in respect to some antigens than to others. Some loci would never lose their active genes. If so, the antigens against which the activity of these genes is directed would be obhgatory in the sense that all immuno- logically competent cells would react against them, given optimal AKR A A ST/A ST/A ST/A DBA/2 DBA/2 DBA/2 DBA/2. Fig. 2. Clonal selection on basis of loss muta
. Ciba Foundation Symposium on Transplantation. Transplantation of organs, tissues, etc. THE FACTOR OF IMMUNIZATION 203 different loci, which fact might reflect that immunological reactivity is more essential for the organism in respect to some antigens than to others. Some loci would never lose their active genes. If so, the antigens against which the activity of these genes is directed would be obhgatory in the sense that all immuno- logically competent cells would react against them, given optimal AKR A A ST/A ST/A ST/A DBA/2 DBA/2 DBA/2 DBA/2. Fig. 2. Clonal selection on basis of loss mutations. conditions for stimulation by the antigen. Other antigens would be more or less facultative in the sense that the genes which determine reactivity against them have been lost in a smaller or greater part of the entire cell population. Facultative antigens, upon their injection, would therefore lead to clonal selection in the sense which Burnet originally visuahzed, while obhgatory antigens would not. Fig. 2 is intended to repre- sent a crude illustration of this hypothesis as applied to the four antigens of the present investigation. The cells I-IV symbohze. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation Symposium on Transplantation (1961 : London, England); Wolstenholme, G. E. W. (Gordon Ethelbert Ward); Cameron, Margaret P. Boston, Little, Brown
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