. Pathogenic micro-organisms, including bacteria and Protozoa; a practical manual for students, physicians and health officers. c conditions in which they are found, theyare considered by some a different species, Herpetomonas tropica,Wright. The form found in infantile splenomegaly may be consid-ered another species, with the name Herpefomcnas infantile, untW furtherstudy. Darling has recently described an organism resembling thatof kala-azar found in a fatal disease of tropical America. Thoughthe organism, he savs, resembles H. Donovani, he thinks it has enoughpoints of difference to be plac
. Pathogenic micro-organisms, including bacteria and Protozoa; a practical manual for students, physicians and health officers. c conditions in which they are found, theyare considered by some a different species, Herpetomonas tropica,Wright. The form found in infantile splenomegaly may be consid-ered another species, with the name Herpefomcnas infantile, untW furtherstudy. Darling has recently described an organism resembling thatof kala-azar found in a fatal disease of tropical America. Thoughthe organism, he savs, resembles H. Donovani, he thinks it has enoughpoints of difference to be placed in a different genus; therefore hegives it the name Histoplasma capsulatnni, and calls the disease his-toplasmosis. He says it differs from H. Donovani in the form andarrangement of its chromatin nucleus and in not possessing a chro- FLAGELLATA. 555 matin rod. It has a refractile achromatic capsule. As he has notyet grown the organism or made studies on its intermediary host, it istoo early to determine whether his generic name will ^ The bodies have been found in large endothelioid cells in the spleen, Fig. 173. fulturiil forms of H. irifnnliiiii, showinK the l!;mcri:ilc type. (After Nicollc). liver, mesenteric glands, bone-marrow, ki(hiey, lungs, testes, skin, ulcersin intestines, and in the polynuclear leukocytes in the peripheral this last situation they are only found in aj)prcciabl( numbers inadvanced cases. 556 PA THOGENIC MICRO-ORGAXISMS. Morphology.—The bodies are circular to elliptical in shape, from2,u to 4/i in diameter, and contain a double nucleus, a large oval oneat one part of the periphery and a small circular or rod-shaped onenear or at the opposite part of the periphery. This smaller bodystains more intensely than the larger one, while the cytoplasm of theparasite stains very dimly, sometimes showing only a faint periph-eral rim. Any nuclear and cytoplasmic staining methods will bringout these points in Zenker-fixed material. Smears stain
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